Emergence and Spread of SARS-CoV-2 Lineages B.1.1.7 and P.1 in Italy.

Emergence and Spread of SARS-CoV-2 Lineages B.1.1.7 and P.1 in Italy.
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DOI:
10.3390/v13050794
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发表时间:
2021-04-29
期刊:
Viruses
影响因子:
--
通讯作者:
Lorusso A
Lorusso A
中科院分区:
其他
文献类型:
--
作者:
Di Giallonardo F;Puglia I;Curini V;Cammà C;Mangone I;Calistri P;Cobbin JCA;Holmes EC;Lorusso A

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意大利的第二波SARS-CoV-2袭击严重,有300多万例病例和10多万例死亡,比2020年8月报告的数字增加了近10倍。在此,我们对2020年1月29日至2021年3月1日期间在意大利采样的6515个SARS-CoV-2序列进行了分析,并显示了不同的谱系如何在封锁限制下多次独立出现。病毒谱系B.1.177在2020年11月成为主要变种,当时病例达到每天4万例的峰值,但自2021年1月以来,它被B.1.1.7“令人担忧的变种”所取代。此外,我们报告从2020年12月起,另一种记录在案的关注变种-谱系p1 -突然增加,很可能是由一次传入意大利引起的。我们再次强调国际输入如何推动新谱系的出现,基因组测序仍应是意大利持续监测的首要任务。
Italy’s second wave of SARS-CoV-2 has hit hard, with more than three million cases and over 100,000 deaths, representing an almost ten-fold increase in the numbers reported by August 2020. Herein, we present an analysis of 6515 SARS-CoV-2 sequences sampled in Italy between 29 January 2020 and 1 March 2021 and show how different lineages emerged multiple times independently despite lockdown restrictions. Virus lineage B.1.177 became the dominant variant in November 2020, when cases peaked at 40,000 a day, but since January 2021 this is being replaced by the B.1.1.7 ‘variant of concern’. In addition, we report a sudden increase in another documented variant of concern—lineage P.1—from December 2020 onwards, most likely caused by a single introduction into Italy. We again highlight how international importations drive the emergence of new lineages and that genome sequencing should remain a top priority for ongoing surveillance in Italy.
SARS-COV-2血统的估计可传播和影响B.1.1.7在英国。
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