Prenatal ethanol exposure impairs sensory processing and habituation to visual stimuli, effects normalized by enrichment of postnatal environmental.
Prenatal ethanol exposure impairs sensory processing and habituation to visual stimuli, effects normalized by enrichment of postnatal environmental.
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DOI：
10.1111/acer.14818
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发表时间：
2022-05
期刊：
影响因子：
--
通讯作者：
Shen, Roh-Yu
中科院分区：
文献类型：
--
作者：
Wang, Ruixiang;Martin, Connor D.;Lei, Anna L.;Hausknecht, Kathryn A.;Turk, Marisa;Micov, Veronika;Kwarteng, Francis;Ishiwari, Keita;Oubraim, Saida;Wang, An-Li;Richards, Jerry B.;Haj-Dahmane, Samir;Shen, Roh-Yu
关键词：
患有胎儿酒精谱系障碍（FASD）的个体通常表现出所有感觉模式的感觉加工缺陷。使用操作性光强化模型，我们测试了产前乙醇暴露（PE）是否会改变操作性反应，从而引发偶然的感觉刺激——光照开始（开灯）和这种行为的习惯化。我们还探讨了出生后环境富集是否可以改善pe诱导的缺陷。在妊娠第8-20天，以0或3 g/kg/乙醇（15% w/v）灌胃妊娠大鼠2次/天，模拟人类妊娠中期重度PE。后代被饲养在标准的住房条件或丰富的条件下。成年雄性和雌性后代分别进行了短通道和长通道的操作性光强化实验。为了进一步表征适应过程，还进行了不适应试验。在短通道程序中，PE导致在标准住房条件下饲养的两性对偶然光照的操作反应增加。由于反应总体下降，在富集条件下饲养的大鼠没有观察到这种效果。此外，在富集条件下饲养的大鼠表现出更大的短期习惯。在长时间的接触过程中，PE大鼠表现出反应增强和长期习惯受损。长时间进入过程促进了对照组和PE大鼠的短期和长期习惯。产前乙醇暴露增加响应偶然的光发作和损害长期的习惯过程。在光照充足的环境中饲养，增加光照的持续时间和频率，可以改善pe诱导的缺陷。pe诱导的效应类似于感觉寻求的增加，这是一种感觉加工缺陷的亚型，在FASD患者中经常观察到。我们的发现可以为研究FASD缺陷的潜在机制以及可能的干预策略提供合适的动物模型。
Individuals with fetal alcohol spectrum disorders (FASD) often show sensory processing deficits in all sensory modalities. Using an operant light reinforcement model, we tested if prenatal ethanol exposure (PE) could alter operant responding to elicit a contingent sensory stimulus - light onset (turning on light) and habituation of this behavior in rats. We also explored if postnatal environmental enrichment could ameliorate PE-induced deficits. Pregnant Sprague Dawley rats were gavaged twice/day with 0 or 3 g/kg/treatment ethanol (15% w/v) during gestational days 8–20, mimicking second-trimester heavy PE in humans. The offspring were reared in the standard housing condition or an enriched condition. Adult male and female offspring underwent an operant light reinforcement experiment with either a short-access or a long-access procedure. A dishabituation test was also conducted to further characterize the habituation process. In the short-access procedure, PE led to increased operant responding to the contingent light-onset in both sexes reared in the standard housing condition. Such an effect was not observed in rats reared in enriched condition due to an overall decrease in responding. Moreover, rats reared in enriched condition showed greater short-term habituation. In the long access procedure, PE rats showed increased responding and impaired long-term habituation. The long-access procedure facilitated both short-term and long-term habituation in control and PE rats. Prenatal ethanol exposure increases responding to contingent light-onset and impairs the long-term habituation process. The PE-induced deficits could be ameliorated by rearing in the enriched environment and increasing the duration and frequency of exposure to light-onset. The PE-induced effects are similar to increased sensation-seeking, a subtype of sensory-processing deficits, which is often observed in individuals with FASD. Our findings could inform a suitable animal model for investigating the underlying mechanisms as well as possible intervention strategies for these deficits in FASD.
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影响因子：
3.2
作者：
Aghaie, Claudia, I;Hausknecht, Kathryn A.;Shen, Roh-Yu
通讯作者：
Shen, Roh-Yu
影响因子：
2.9
作者：
Hannigan, JH;Berman, RF
通讯作者：
Berman, RF
影响因子：
7.6
作者：
Hausknecht, Kathryn;Haj-Dahmane, Samir;Shen, Roh-Yu
通讯作者：
Shen, Roh-Yu
影响因子：
1.3
作者：
Cain, Mary E.;Green, Thomas A.;Bardo, Michael T.
通讯作者：
Bardo, Michael T.
影响因子：
2.9
作者：
BARRON, S;RILEY, EP
通讯作者：
RILEY, EP