Shared functional connections within and between cortical networks predict cognitive abilities in adult males and females.
Shared functional connections within and between cortical networks predict cognitive abilities in adult males and females.
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DOI：
10.1002/hbm.25709
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发表时间：
2022-02-15
影响因子：
4.8
通讯作者：
Kuceyeski A
中科院分区：
文献类型：
--
作者：
Dhamala E;Jamison KW;Jaywant A;Kuceyeski A
彻底了解构成健康个体认知能力的性别独立和性别特异性的神经生物学特征，对于研究神经疾病至关重要，在这些疾病中，男性和女性表现出不同的认知障碍。在这里，我们评估了来自人类连接组项目的392名健康年轻人(196名男性)的功能连接性和个体认知能力之间的性别独立和性别特异性关系。首先，我们建立了性别无关的模型，可以比较地预测男性和女性的结晶能力，但只成功地预测了男性的流动能力。其次，我们证明了性别特定的模型可以比较地预测性别内部和性别之间的具体化能力，而通常无法预测任何性别的流动能力。第三，我们发现，在男性和女性中，视觉、背侧注意、腹侧注意和颞顶网络之间的大部分重叠连接与在结晶和流体认知测试中的较好表现有关，而视觉、躯体运动和颞顶网络内的连接与较差的表现相关。总而言之，我们的发现表明，功能性连接体的共同神经生物学特征是两性结晶和流动能力的基础。在这里，我们评估了来自人类连接组项目的392名健康年轻人(196名男性)的功能连接性和个体认知能力之间的性别独立和性别特异性关系。我们确定，性别无关的模型可以比较地预测男性和女性的结晶能力，但只能成功地预测男性的流动能力，而性别特定的模型可以比较地预测性别内部和性别之间的结晶能力，通常无法预测两种性别的流动能力。我们还证明，在男性和女性中，视觉、背侧注意、腹侧注意和颞顶网络之间的大部分重叠连接与在结晶和流体认知测试中的较好表现有关，而视觉、躯体运动和颞顶网络内的连接与较差的表现相关。
A thorough understanding of sex‐independent and sex‐specific neurobiological features that underlie cognitive abilities in healthy individuals is essential for the study of neurological illnesses in which males and females differentially experience and exhibit cognitive impairment. Here, we evaluate sex‐independent and sex‐specific relationships between functional connectivity and individual cognitive abilities in 392 healthy young adults (196 males) from the Human Connectome Project. First, we establish that sex‐independent models comparably predict crystallised abilities in males and females, but only successfully predict fluid abilities in males. Second, we demonstrate sex‐specific models comparably predict crystallised abilities within and between sexes, and generally fail to predict fluid abilities in either sex. Third, we reveal that largely overlapping connections between visual, dorsal attention, ventral attention, and temporal parietal networks are associated with better performance on crystallised and fluid cognitive tests in males and females, while connections within visual, somatomotor, and temporal parietal networks are associated with poorer performance. Together, our findings suggest that shared neurobiological features of the functional connectome underlie crystallised and fluid abilities across the sexes. Here, we evaluate sex‐independent and sex‐specific relationships between functional connectivity and individual cognitive abilities in 392 healthy young adults (196 males) from the Human Connectome Project. We establish that sex‐independent models comparably predict crystallised abilities in males and females, but only successfully predict fluid abilities in males, while sex‐specific models comparably predict crystallised abilities within and between sexes, and generally fail to predict fluid abilities in either sex. We also demonstrate that largely overlapping connections between visual, dorsal attention, ventral attention, and temporal parietal networks are associated with better performance on crystallised and fluid cognitive tests in males and females, while connections within visual, somatomotor, and temporal parietal networks are associated with poorer performance.
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影响因子：
2.7
作者：
Carlozzi NE;Tulsky DS;Wolf TJ;Goodnight S;Heaton RK;Casaletto KB;Wong AWK;Baum CM;Gershon RC;Heinemann AW
通讯作者：
Heinemann AW
影响因子：
25
作者：
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2.5
作者：
AERTSEN, AMHJ;GERSTEIN, GL;PALM, G
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PALM, G
基于ICA的人工制品去除和加速fMRI获取，以改善静止状态网络成像。
影响因子：
5.7
作者：
Griffanti L;Salimi-Khorshidi G;Beckmann CF;Auerbach EJ;Douaud G;Sexton CE;Zsoldos E;Ebmeier KP;Filippini N;Mackay CE;Moeller S;Xu J;Yacoub E;Baselli G;Ugurbil K;Miller KL;Smith SM
通讯作者：
Smith SM