Cytomegalovirus infection: friend or foe in rheumatoid arthritis?
Cytomegalovirus infection: friend or foe in rheumatoid arthritis?
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DOI：
10.1186/s13075-020-02398-3
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发表时间：
2021-01-07
影响因子：
4.9
通讯作者：
Cantagrel A
中科院分区：
文献类型：
--
作者：
Davignon JL;Combe B;Cantagrel A
人类巨细胞病毒 (HCMV) 是一种 β-疱疹病毒，会引起炎症并在宿主体内终生处于潜伏状态。 HCMV 一直是有关 RA 的许多假设的中心。我们最近发现，HCMV 感染通过诱导 mRNA 结合蛋白 QKI5 来损害骨侵蚀。全国队列患者中，潜伏感染的 RA 患者骨侵蚀进展较慢。我们的观察结果质疑 HCMV 与 RA 病理生理学之间可能存在的关联。在这篇综述中，我们研究了 HCMV 在防止骨侵蚀的同时可能是 RA 炎症加重因素的可能性。我们还评估了它与其他病原体的关系，例如引起牙周炎和产生 ACPA 的细菌。因此，本综述考虑了 HCMV 在 RA 的发病机制和病程中到底是朋友还是敌人。
Human cytomegalovirus (HCMV) is a β-herpesvirus that causes inflammation and remains for life in a latent state in their host. HCMV has been at the center of many hypotheses regarding RA. We have recently shown that HCMV infection impairs bone erosion through the induction of the mRNA-binding protein QKI5. Latently infected RA patients display a slower progression of bone erosion in patients from a national cohort. Our observations question the possible association between HCMV and the pathophysiology of RA. In this review, we examine the possibility that HCMV may be an aggravating factor of inflammation in RA while protecting from bone erosion. We also assess its relationship with other pathogens such as bacteria causing periodontitis and responsible for ACPA production. This review thus considers whether HCMV can be regarded as a friend or a foe in the pathogenesis and the course of RA.
影响因子：
4.9
作者：
Davis JM 3rd;Knutson KL;Skinner JA;Strausbauch MA;Crowson CS;Therneau TM;Wettstein PJ;Matteson EL;Gabriel SE
通讯作者：
Gabriel SE