A profile of immune response to herpesvirus is associated with radiographic joint damage in rheumatoid arthritis.
A profile of immune response to herpesvirus is associated with radiographic joint damage in rheumatoid arthritis.
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DOI：
10.1186/ar3706
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发表时间：
2012-01-31
影响因子：
4.9
通讯作者：
Gabriel SE
中科院分区：
文献类型：
--
作者：
Davis JM 3rd;Knutson KL;Skinner JA;Strausbauch MA;Crowson CS;Therneau TM;Wettstein PJ;Matteson EL;Gabriel SE
尽管进行了适当的治疗，关节损伤的进展仍然是类风湿性关节炎（RA）患者的一个重大问题。这项研究的目的是确定与放射学关节损伤相关的免疫反应概况，作为发现 RA 关节破坏新致病机制的第一步。该研究包括 58 名 RA 患者和 15 名健康对照者。测量了外周血单核细胞 (PBMC) 响应六种刺激之一或仅在培养基中刺激 48 小时后释放的细胞因子的情况。在多变量调整之前和之后，针对每种刺激确定的免疫反应概况与由 Sharp-van der Heijde 评分 (SHS) 定义的放射学关节损伤相关。对于与 SHS 相关的概况，根据关节损伤的严重程度评估患者个体细胞因子的分布，并与健康对照进行比较。巨细胞病毒 (CMV)/EB 病毒 (EBV) 刺激的免疫反应特征与 SHS 总分和侵蚀评分相关（分别为 r = 0.31，P = 0.018 和 r = 0.33，P = 0.011）。调整年龄、性别、病程、自身抗体状态、CMV/EBV血清学状态、当前疾病活动度、残疾和治疗后，CMV/EBV免疫反应与SHS侵蚀评分的相关性变得更强(r = 0.43，P < 0.003)。 CMV/EBV 免疫反应与 CMV IgG 相关（r = 0.44，P < 0.001），但与 EBV IgG 无关。 CMV/EBV 免疫反应谱中最重要的细胞因子是 IFN-γ、IL-2、IL-4、IL-5、IL-13 和 IL-17A，所有这些都与 T 细胞免疫相关。免疫反应总分以及 IFN-γ 和 IL-13 对 CMV/EBV 刺激的个体反应均与更大的关节损伤相关。对纯化的 CMV/EBV 裂解物的免疫反应概况与放射学关节损伤有关。这种免疫反应与 CMV 血清学的相关性表明可能涉及潜在的 CMV 感染。因此，研究结果表明，对潜伏巨细胞病毒感染的免疫反应可能在 RA 患者炎症和结构性关节损伤的进展中发挥重要作用。
Progression of joint damage despite appropriate therapy remains a significant problem for patients with rheumatoid arthritis (RA). This study was undertaken to identify profiles of immune response that correlate with radiographic joint damage as a first step toward the discovery of new pathogenic mechanisms of joint destruction in RA. The study included 58 patients with RA and 15 healthy controls. The profiles of cytokine release from peripheral blood mononuclear cells (PBMC) in response to stimulation for 48 hours with one of six stimuli, or in media alone, were measured. Immune response profiles identified for each stimulus were correlated with radiographic joint damage as defined by the Sharp-van der Heijde score (SHS), before and after multivariable adjustment. For profiles correlated with the SHS, the distributions of individual cytokines were evaluated in patients according to the severity of joint damage and compared to healthy controls. The immune response profile for cytomegalovirus (CMV)/Epstein-Barr virus (EBV) stimulation was correlated with both the SHS total and erosion scores (r = 0.31, P = 0.018 and r = 0.33, P = 0.011, respectively). After adjusting for age, sex, disease duration, autoantibody status, CMV/EBV serological status, current disease activity, disability and treatments, the correlation of the CMV/EBV immune response and the SHS erosion score became stronger (r = 0.43, P < 0.003). The CMV/EBV immune response correlated with CMV IgG (r = 0.44, P < 0.001), but not with EBV IgG. The most important cytokines for the CMV/EBV immune response profile were IFN-γ, IL-2, IL-4, IL-5, IL-13 and IL-17A, all of which are associated with T-cell immunity. Both the summary immune response score and the individual responses of IFN-γ and IL-13 to CMV/EBV stimulation were associated with greater joint damage. A profile of immune response to purified CMV/EBV lysates is associated with radiographic joint damage. The correlation of this immune response to CMV serology implies possible involvement of latent CMV infection. Therefore, the findings suggest that the immune response to latent CMV infection could play a fundamental role in the progression of inflammation and structural joint damage in patients with RA.
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影响因子：
--
作者：
Davis, John M., III;Knutson, Keith L.;Gabriel, Sherine E.
通讯作者：
Gabriel, Sherine E.
影响因子：
15.9
作者：
FERRELL, PB;AITCHESON, CT;TAN, EM
通讯作者：
TAN, EM
DOI：
10.1073/pnas.76.11.5825
发表时间：
1979-01-01
影响因子：
11.1
作者：
CATALANO, MA;CARSON, DA;VAUGHAN, JH
通讯作者：
VAUGHAN, JH
DOI：
10.4049/jimmunol.0904180
发表时间：
2010-06-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Davis JM 3rd;Knutson KL;Strausbauch MA;Crowson CS;Therneau TM;Wettstein PJ;Matteson EL;Gabriel SE
通讯作者：
Gabriel SE
影响因子：
4.4
作者：
Fiola, Stephanie;Gosselin, David;Gosselin, Jean
通讯作者：
Gosselin, Jean