ER-mitochondria signaling in Parkinson's disease.
ER-mitochondria signaling in Parkinson's disease.
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DOI：
10.1038/s41419-017-0079-3
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发表时间：
2018-03-01
影响因子：
9
通讯作者：
Niso-Santano M
中科院分区：
文献类型：
--
作者：
Gómez-Suaga P;Bravo-San Pedro JM;González-Polo RA;Fuentes JM;Niso-Santano M
线粒体与内质网（ER）的一个专门结构域形成密切的物理接触，该结构域被称为线粒体相关膜（MAM）。这种关联构成了调节几个基本细胞过程的关键信号中枢。ER-线粒体信号转导的改变对多种细胞内事件具有多效性作用，导致线粒体损伤、Ca 2+稳态异常、ER应激以及脂质代谢和自噬的缺陷。有趣的是，许多这些细胞过程在神经退行性疾病中受到干扰。此外，越来越多的证据强调ER-线粒体信号传导有助于这些疾病，包括帕金森病（PD）。PD是第二种最常见的神经退行性疾病，其有效的基于机制的治疗仍然难以捉摸。几种PD相关蛋白定位于线粒体或MAM，并已被证明参与ER-线粒体信号转导调节。同样，PD相关的突变已被证明会破坏这种信号传导。ER-线粒体相关性是否是PD致病机制之间的联系，提供了一个共同的机制？这会为治疗这种毁灭性疾病提供一个药理学靶点吗？在这篇综述中，我们的目的是总结目前的知识ER-线粒体信号和最近的证据有关的损害，这种信号在PD。
Mitochondria form close physical contacts with a specialized domain of the endoplasmic reticulum (ER), known as the mitochondria-associated membrane (MAM). This association constitutes a key signaling hub to regulate several fundamental cellular processes. Alterations in ER–mitochondria signaling have pleiotropic effects on a variety of intracellular events resulting in mitochondrial damage, Ca2+ dyshomeostasis, ER stress and defects in lipid metabolism and autophagy. Intriguingly, many of these cellular processes are perturbed in neurodegenerative diseases. Furthermore, increasing evidence highlights that ER–mitochondria signaling contributes to these diseases, including Parkinson’s disease (PD). PD is the second most common neurodegenerative disorder, for which effective mechanism-based treatments remain elusive. Several PD-related proteins localize at mitochondria or MAM and have been shown to participate in ER–mitochondria signaling regulation. Likewise, PD-related mutations have been shown to damage this signaling. Could ER–mitochondria associations be the link between pathogenic mechanisms involved in PD, providing a common mechanism? Would this provide a pharmacological target for treating this devastating disease? In this review, we aim to summarize the current knowledge of ER–mitochondria signaling and the recent evidence concerning damage to this signaling in PD.
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影响因子：
3.5
作者：
De Vos KJ;Mórotz GM;Stoica R;Tudor EL;Lau KF;Ackerley S;Warley A;Shaw CE;Miller CC
通讯作者：
Miller CC
影响因子：
64.5
作者：
Cárdenas C;Miller RA;Smith I;Bui T;Molgó J;Müller M;Vais H;Cheung KH;Yang J;Parker I;Thompson CB;Birnbaum MJ;Hallows KR;Foskett JK
通讯作者：
Foskett JK
DOI：
10.1126/science.aab1370
发表时间：
2015-07-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Chung J;Torta F;Masai K;Lucast L;Czapla H;Tanner LB;Narayanaswamy P;Wenk MR;Nakatsu F;De Camilli P
通讯作者：
De Camilli P
DOI：
10.1016/j.bbadis.2013.01.004
发表时间：
2013-04-01
影响因子：
6.2
作者：
Cali, Tito;Ottolini, Denis;Brini, Marisa
通讯作者：
Brini, Marisa
影响因子：
4.8
作者：
Cali, Tito;Fedrizzi, Laura;Brini, Marisa
通讯作者：
Brini, Marisa