Immunocytochemical studies of endothelial cells in vivo. I. The presence of desmin only, or of desmin plus vimentin, or vimentin only, in the endothelial cells of different capillaries of the adult chicken
Immunocytochemical studies of endothelial cells in vivo. I. The presence of desmin only, or of desmin plus vimentin, or vimentin only, in the endothelial cells of different capillaries of the adult chicken
复制标题
体内内皮细胞的免疫细胞化学研究。
作者：
T. Fujimoto;S. Singer
目前认为内皮细胞的中间丝只含有波形蛋白亚基。然而，这一推论仅来自对少数几种内皮细胞的研究。通过双间接免疫荧光和免疫电子显微镜，我们在体内检测了成年鸡多种组织和器官的微血管和大血管内皮细胞中desmin和vimentin的含量。肾皮质小管周围毛细血管内皮细胞、肝窦和脾窦仅含desmin；外分泌胰腺毛细血管同时含有促球蛋白和波形蛋白；大血管和其他微血管的内皮细胞，包括肾髓质的直血管，只含有静脉蛋白。这种异质性表明不同类型的成年鸡内皮细胞可能具有不同的胚胎起源。在一定程度上，聚丝蛋白和波形蛋白中间丝可能具有不同的功能，这些结果也表明不同的毛细血管内皮细胞可能具有不同的功能特性。
It is currently believed that the intermediate filaments of endothelial cells contain vimentin subunits exclusively. This inference, however, is derived from studies of only a few types of endothelial cells. By double indirect immunofluorescence and immunoelectron microscopy, we have now examined the endothelial cells of the micro- and macrovasculature of a variety of tissues and organs of adult chicken in vivo for their content of desmin and vimentin. Endothelial cells of the peritubular capillary in the renal cortex, the hepatic sinusoid, and the splenic sinusoid were found to contain only desmin; those of the exocrine pancreas capillary contained both desmin and vimentin; and the endothelial cells of the macrovasculatures and of all the other microvasculatures examined, including the vasa recta of the renal medulla, contained only vimentin. Such heterogeneity suggests that different types of adult chicken endothelial cells may have different embryological origins. To the extent that desmin and vimentin intermediate filaments may be functionally distinct, these results also suggest that different capillary endothelial cells may have different functional properties.
影响因子：
29.4
作者：
M. G. Irving;F. Roll;Sandra Huang;D. Bissell
通讯作者：
M. G. Irving;F. Roll;Sandra Huang;D. Bissell