The distinct expression patterns of claudin-10, -14, -17 and E-cadherin between adjacent non-neoplastic tissues and gastric cancer tissues.
The distinct expression patterns of claudin-10, -14, -17 and E-cadherin between adjacent non-neoplastic tissues and gastric cancer tissues.
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DOI：
10.1186/1746-1596-8-205
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发表时间：
2013-12-10
影响因子：
2.6
通讯作者：
Wang G
中科院分区：
文献类型：
--
作者：
Gao M;Li W;Wang H;Wang G
最近的数据表明，细胞粘附蛋白在几种人类癌症中受到异常调节，并且细胞粘附蛋白E-钙粘蛋白和密蛋白的表达参与癌症的病因和进展。显然，这些蛋白质代表了癌症检测、诊断和治疗的有希望的靶标。为了探讨细胞粘附蛋白claudin-10,-14,-17和E-cadherin在癌旁非肿瘤组织和胃癌组织中的表达差异，采用链霉亲和素-过氧化物酶免疫组化染色法检测50例胃癌组织和50例癌旁非肿瘤组织中claudin-10,-14,-17和E-cadherin的表达情况。胃癌组织和癌旁非肿瘤组织中E-cadherin的阳性表达率分别为32%和74%(P<0.01)。胃癌组织和癌旁非肿瘤组织中claudin-10的阳性表达率分别为24%和72%(P<0.01)。胃癌组织和癌旁非肿瘤组织中claudin-17的阳性表达率分别为18%和70%（P<0.01）。相比之下,胃癌组织和癌旁非肿瘤组织中claudin-14的阳性表达率分别为58%和24%(P = 0.015 < 0.05)。因此本研究中胃癌组织中E-cadherin、claudin-10、claudin-17的表达量下调,而claudin-14的表达量上调。观察claudins和E-cadherin表达与淋巴转移的相关性。我们的研究发现胃癌组织中E-cadherin、claudin-10、claudin-17的表达下调,claudin-14的表达上调,并观察claudins、E-cadherin表达与淋巴结转移的相关性。本文的虚拟幻灯片可以在这里找到：http://www.diagnosticpathology.diagnomx.eu/vs/1475928069111326。
Recent data indicate that the cell adhesion proteins are abnormally regulated in several human cancers and the expression of the cell adhesion proteins E-cadherin and claudin proteins is involved in the etiology and progression of cancer. It is clear that these protein represent promising targets for cancer detection, diagnosis, and therapy. To explore the expression distinction of the cell adhesion proteins claudin-10,-14,-17 and E-cadherin in the adjacent non-neoplastic tissues and gastric cancer tissues, 50 gastric cancer tissues and 50 samples of adjacent non-neoplastic tissues adjacent to the tumors were examined for expression of claudin-10,-14,-17 and E-cadherin by streptavidin-perosidase immunohistochemical staining method. The positive expression rates of E-cadherin in gastric cancer tissues and adjacent non-neoplastic tissues were 32% and 74% respectively (P < 0.01). The positive expression rates of claudin-10 in gastric cancer tissues and adjacent non-neoplastic tissues were 24% and 72% respectively (P < 0.01). The positive expression rates of claudin-17 in gastric cancer tissues and adjacent non-neoplastic tissues were 18% and 70% (P < 0.01). In contrast, the positive expression rates of claudin-14 in gastric cancer tissues and adjacent non-neoplastic tissues were 58% and 24% respectively (P = 0.015 < 0.05) Thus in our study, the expression of E-cadherin, claudin-10, and claudin-17 was down-regulated in gastric cancer tissue while the expression of claudin-14 was up-regulated. Correlations between claudins and E-cadherin expression with lymphatic metastasis were observed. Our study reveals that the expression of E-cadherin, claudin-10, and claudin-17 were down-regulated in gastric cancer tissue while the expression of claudin-14 was up-regulated and correlation between claudins and E-cadherin expression with lymphatic metastasis were observed. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1475928069111326.
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