Highly Stretchable, Strain Sensing Hydrogel Optical Fibers.
Highly Stretchable, Strain Sensing Hydrogel Optical Fibers.
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DOI：
10.1002/adma.201603160
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发表时间：
2016-12
影响因子：
29.4
通讯作者：
Yun, Seok-Hyun
中科院分区：
文献类型：
--
作者：
Guo, Jingjing;Liu, Xinyue;Jiang, Nan;Yetisen, Ali K.;Yuk, Hyunwoo;Yang, Changxi;Khademhosseini, Ali;Zhao, Xuanhe;Yun, Seok-Hyun
水凝胶被广泛用于组织工程、药物输送、[2]和伤口敷料。[3]最近，人们努力将光子功能集成到水凝胶材料中，用于新型生物医学应用，包括用于光传输和监测生物组织中血液氧合水平的功能光纤，[4]用于毒性传感和光遗传疗法的含有细胞的水凝胶植入物，[5]和用于检测生化分析物的纳米颗粒包埋水凝胶。[6]然而，由于常见的合成水凝胶的脆弱和易碎的性质，[7]这些水凝胶光子设备相对脆弱的外部应力和应变。较低的机械强度对这些水凝胶在可穿戴或可植入设备中的应用提出了实际挑战，因为身体运动和组织运动可能会降低或破坏结构和功能。[8]已经证明了许多聚合物凝胶获得机械韧性、弹性和弹性以及柔韧性的配方。最有前景的方法之一是形成离子和共价聚合物网络的杂化，其中共价交联的长链聚合物赋予水凝胶很高的伸长性，而可重构的离子交联聚合物通过在变形时耗散机械能来增强水凝胶的韧性。[11]离子交联的海藻酸盐和共价交联的聚丙烯酰胺杂化网络表现出显著的拉伸能力、高达9000 J m−2的高断裂能[11]和生物相容性。[7，12]尽管最近水凝胶的力学性能得到了增强，但高度可伸展和坚固的水凝胶光子器件尚未实现我们报道了由光学优化的海藻酸盐-聚丙烯酰胺水凝胶材料制成的具有芯/包层阶跃结构的高度可伸展和坚韧的光纤的设计和制造(图S1)。纤维可以拉伸到700%的轴向应变，然后在多个循环中松弛。功能分子，如有机染料，也可以通过溶液掺杂进入水凝胶的多孔基质中。利用这些独特的性质，我们设计了一种新颖、简单的轴向应变测量技术，并基于大动态应变范围的染料掺杂水凝胶纤维实现了分布式应变传感。
Hydrogels are widely used in tissue engineering,[1] drug delivery,[2] and wound dressings.[3] Recently, efforts have been made to integrate photonic functions into hydrogel materials for novel biomedical applications, including functional optical fibers for light delivery and monitoring of blood oxygenation levels in biological tissues,[4] cell-containing hydrogel implants for toxicity sensing and optogenetic therapy,[5] and nanoparticle-embedded hydrogels for detection of biochemical analytes.[6] However, due to the weak and brittle nature of common synthetic hydrogels,[7] these hydrogel photonic devices are relatively fragile against external stress and strain. The low mechanical strength poses a practical challenge for these hydrogels’ applications in wearable or implantable devices because the body motion and tissue movement may degrade or damage the structure and function.[8] A number of recipes for polymer gels to obtain mechanical toughness, resilience, and elasticity, as well as flexibility have been demonstrated.[9, 10] One of the most promising approaches is to form a hybrid of ionic and covalent polymer networks where the covalently crosslinked long-chain polymers give high stretchability of the hydrogel and the reconfigurable ionically crosslinked polymers enhance the hydrogel’s toughness by dissipating mechanical energy under deformation.[11] The hybrid network of ionically crosslinked alginate and covalently crosslinked polyacrylamide has shown remarkable stretching capability, high fracture energy of~ 9,000 J m− 2,[11] and biocompatibility.[7, 12] Despite recent enhancements of hydrogels’ mechanical properties, highly stretchable and robust hydrogel photonic devices have not been achieved yet.Here, we report the design and fabrication of highly stretchable and tough optical fibers made of optically-optimized alginate-polyacrylamide hydrogel materials in a core/clad stepindex structure (Figure S1). The fibers can be elongated to an axial strain of 700% and then relaxed over multiple cycles. Functional molecules, such as organic dyes, may also be incorporated into the porous matrix of hydrogels by solution doping. Harnessing these unique properties, we have devised a novel, simple technique for measuring axial strain and accomplished distributed strain sensing based on dye-doped hydrogel fibers with a large dynamic strain range.
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影响因子：
3.4
作者：
Applegate, Matthew B.;Perotto, Giovanni;Omenetto, Fiorenzo G.
通讯作者：
Omenetto, Fiorenzo G.
DOI：
10.1002/adma.201504152
发表时间：
2016-06
期刊：
Advanced materials (Deerfield Beach, Fla.)
影响因子：
--
作者：
Lin S;Yuk H;Zhang T;Parada GA;Koo H;Yu C;Zhao X
通讯作者：
Zhao X
影响因子：
35
作者：
通讯作者：
--
影响因子：
64.8
作者：
Sun, Jeong-Yun;Zhao, Xuanhe;Illeperuma, Widusha R. K.;Chaudhuri, Ovijit;Oh, Kyu Hwan;Mooney, David J.;Vlassak, Joost J.;Suo, Zhigang
通讯作者：
Suo, Zhigang
影响因子：
4.6
作者：
Kizilay, MY;Okay, O
通讯作者：
Okay, O