Comparison of disulfiram and placebo in treatment of alcohol dependence of adolescents.
Comparison of disulfiram and placebo in treatment of alcohol dependence of adolescents.
复制标题
双硫仑和安慰剂治疗青少年酒精依赖的比较。
作者：
H. Niederhofer;W. Staffen
大约50%的酒精中毒患者在治疗后3个月内复发。以前的研究表明，双硫仑可能有助于防止这种复发。本研究的目的是评估长期双硫仑治疗青少年酒精依赖的有效性和安全性。在这项双盲、安慰剂对照研究中，我们招募了26名16 - 19岁的慢性或间歇性酒精依赖青少年。患者随机分配双硫仑（每日200 mg）或安慰剂治疗90天。在治疗开始当天以及第30天和第90天通过访谈、自我报告、问卷调查和实验室筛查对患者进行评估。患者被分类为禁欲，复发或非参加。至首次治疗失败的时间（复发或未就诊）是主要结局指标。双硫仑组（n = 13）和安慰剂组（n = 13）在基线人口统计学和酒精相关变量方面匹配良好。13例双硫仑治疗患者和13例安慰剂治疗患者完成了治疗期; 7例（1 vs. 6）复发，5例（3 vs. 2）拒绝继续治疗，3例（1 vs. 2）合并疾病，2例（1 vs. 1）出现不良副作用。在治疗结束时，7例双硫仑治疗患者和2例安慰剂治疗患者持续戒断（p = 0.0063）。双硫仑组的平均累积戒断持续时间显著长于安慰剂组[68.5（SD 37.5）vs. 29.7（19.0）天; p = 0.012]。除了偶尔腹泻外，两组之间的副作用没有差异。在某些情况下，双硫仑可能是治疗青少年酒精依赖患者的心理社会和行为治疗方案的有效且耐受性良好的药理学辅助药物。
About 50% of alcoholic patients relapse within 3 months of treatment. Previous studies have suggested that disulfiram may help to prevent such relapse. The aim of our study was to assess the efficacy and safety of long-term disulfiram treatment in alcohol dependence of adolescents. In this double-blind, placebo-controlled study we recruited 26 adolescents, aged 16-19 years, with chronic or episodic alcohol dependence. Patients were allocated treatment randomly with disulfiram (200 mg daily) or placebo for 90 days. Patients were assessed on the day treatment started and on days 30 and 90 by interview, self-report, questionnaire and laboratory screening. Patients were classified as abstinent, relapsing or non-attending. Time to first treatment failure (relapse or non-attendance) was the primary outcome measure. The disulfiram (n=13) and placebo (n=13) groups were well matched in terms of baseline demographic and alcohol-related variables. Thirteen disulfiram-treated and 13 placebo-treated patients completed the treatment phase; seven (1 vs. 6) relapsed, five (3 vs. 2) refused to continue treatment, three (1 vs. 2) had concurrent illness and two (1 vs. 1) had adverse side effects. At the end of treatment, seven disulfiram-treated and two placebo-treated patients had been abstinent continuously (p=0.0063). Mean cumulative abstinence duration was significantly greater in the disulfiram group than in the placebo group [68.5 (SD 37.5) vs. 29.7 (19.0) days; p=0.012]. Apart from occasional diarrhoea, there was no difference in side effects between groups. In some cases, disulfiram may be an effective and well-tolerated pharmacological adjunct to psychosocial and behavioural treatment programmes for treatment of adolescent alcohol-dependent patients.
影响因子：
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作者：
Volpicelli,JR;Alterman,AI;Hayashida,M;O'Brien,CP
通讯作者：
O'Brien,CP
氟西汀作为预防酗酒者复发的辅助手段的安慰剂对照试验。
DOI：
10.1176/ajp.152.3.391
发表时间：
1995
期刊：
The American journal of psychiatry.
影响因子：
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作者：
Kranzler,HR;Burleson,JA;Korner,P;DelBoca,FK;Bohn,MJ;Brown,J;Liebowitz,N
通讯作者：
Liebowitz,N