Placebo-controlled trial of fluoxetine as an adjunct to relapse prevention in alcoholics.
Placebo-controlled trial of fluoxetine as an adjunct to relapse prevention in alcoholics.
复制标题
氟西汀作为预防酗酒者复发的辅助手段的安慰剂对照试验。
DOI：
10.1176/ajp.152.3.391
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Liebowitz,N
中科院分区：
文献类型：
--
作者：
Kranzler,HR;Burleson,JA;Korner,P;DelBoca,FK;Bohn,MJ;Brown,J;Liebowitz,N
作者检验了氟西汀与复发预防心理治疗联合使用时直接降低酗酒者复发频率和严重程度的假设。氟西汀的安慰剂对照试验（最多60 mg/天），持续12周，同时每周进行一次心理治疗，受试者没有选择的基础上共病的抑郁症。治疗结束时和6个月后treatment. ResultsPlacebo治疗的受试者更抱怨的药物治疗方案，并留在研究中的时间比氟西汀治疗的受试者。治疗期间两组的饮酒量均显著低于治疗前。这些影响在给药后持续存在。虽然氟西汀治疗酒精消费量没有显着的影响，它减少了汉密尔顿抑郁量表评分比安慰剂治疗的受试者与当前的主要depression.ConclusionsFluoxetine在60毫克/天的剂量可能不是用于预防复发的酗酒者与轻度至中度酒精依赖，没有共病抑郁症。在重度抑郁症的酗酒者中，这种药物可以减轻抑郁症状。后续的氟西汀研究可能应该关注更严重的酒精依赖受试者或合并抑郁症的受试者。
ObjectiveThe authors tested the hypothesis that fluoxetine, when used in combination with relapse prevention psychotherapy, directly reduces relapse frequency and severity for alcoholics.MethodThe authors conducted a randomized, placebo-controlled trial of fluoxetine (up to a maximum of 60 mg/day) for 12 weeks in combination with weekly psychotherapy for 101 alcohol-dependent subjects who were not selected on the basis of comorbid major depression. Outcomes were measured at the end of treatment and 6 months after treatment.ResultsPlacebo-treated subjects were more complaint with the medication regimen and remained in the study longer than fluoxetine-treated subjects. There was significantly less alcohol consumption in both groups during treatment than before treatment. These effects persisted during the posttreatment period. Although fluoxetine treatment had no significant effects on alcohol consumption, it reduced Hamilton Depression Rating Scale scores more than placebo treatment among subjects with current major depression.ConclusionsFluoxetine at a dose of 60 mg/day is probably not of use for relapse prevention in alcoholics with mild to moderate alcohol dependence and no comorbid depression. In alcoholics with major depression, the drug may reduce depressive symptoms. Subsequent studies with fluoxetine should probably focus on more severely alcohol-dependent subjects or those with comorbid depression.
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影响因子：
56.9
作者：
CLONINGER, CR
通讯作者：
CLONINGER, CR
齐美立定引起非抑郁重度饮酒者的酒精摄入量变化
DOI：
--
发表时间：
1984
期刊：
Clinical pharmacology and therapy
影响因子：
--
作者：
C. Naranjo;E. Sellers;C. Roach;Denise V Woodley;M. Sanchez;K. Sykora
通讯作者：
K. Sykora
氟西汀和 ca-乙酰基高牛磺酸盐对家族性和非家族性酗酒患者酒精摄入量的影响
DOI：
--
发表时间：
1992
期刊：
影响因子：
--
作者：
G. Gerra;R. Caccavari;R. Delsignore;R. Bocchi;G. Fertonani;M. Passeri
通讯作者：
M. Passeri
影响因子：
--
作者：
R. Spitzer;Janet B W Williams;M. Gibbon;M. First
通讯作者：
R. Spitzer;Janet B W Williams;M. Gibbon;M. First
影响因子：
11.3
作者：
BLOUIN, AG;PEREZ, EL;BLOUIN, JH
通讯作者：
BLOUIN, JH