Is impaired memory for spatial location in Parkinson's disease domain specific or dependent on ‘strategic’ processes?
Is impaired memory for spatial location in Parkinson's disease domain specific or dependent on ‘strategic’ processes?
复制标题
帕金森病领域的空间位置记忆受损是特定的还是依赖于“战略”过程？
DOI：
10.1016/s0028-3932(97)00102-4
复制
发表时间：
1998
期刊：
影响因子：
2.6
通讯作者：
B. Dubois
中科院分区：
文献类型：
--
作者：
B. Pillon;B. Deweer;M. Vidailhet;A. Bonnet;V. Hahn;B. Dubois
研究发现，帕金森病 (PD) 患者的空间记忆受损。为了确定缺陷的性质，我们将“标准”左旋多巴治疗的 PD 患者与匹配对照受试者在不同情况下的表现进行了比较：（i）空间与语言条件联想学习； (ii)“全局”与“本地”上下文编码； (iii) 模式跨度和相关的超跨度学习。通过比较尚未接受治疗的“从头”帕金森病患者与匹配的对照受试者的表现，研究了该疾病的特征——多巴胺能耗竭与记忆过程受损之间的关系。两组PD患者在所有需要策略过程的情况下均受到损害，共同的模式跨度减小，并且一旦考虑到模式跨度，则具有正常的视觉空间学习。所有这些结果表明，PD 中观察到的空间位置记忆缺陷主要是由于战略过程的干扰和注意力资源减少造成的，这可能至少部分是由于多巴胺能耗竭和相关的纹状体额叶功能障碍。
Spatial memory has been found to be impaired in Parkinson's disease (PD). To determine the nature of the deficit, we compared the performance of ‘standard’ levodopa-treated patients with PD to that of matched control subjects in different situations: (i) spatial versus verbal conditional associative learning; (ii) ‘global’ versus ‘local’ contextual encoding; (iii) pattern span and related supraspan learning. The relationship between dopaminergic depletion, which characterizes the disease, and the impaired memory processes was investigated by comparing the performance of ‘de novo’ not yet treated PD patients to that of matched control subjects. Both groups of PD patients were impaired in all situations requiring strategic processes, shared a decreased pattern span and had a normal visuospatial learning once the pattern span was taken into account. All these results suggest that the memory deficit for spatial location observed in PD results mainly from a disturbance of strategic processes and from decreased attentional resources, which may be due, at least in part, to the dopaminergic depletion and related striatofrontal dysfunction.
影响因子：
--
作者：
BOLLER, F;PASSAFIUME, D;KIM, Y
通讯作者：
KIM, Y
影响因子：
14.5
作者：
COOPER, JA;SAGAR, HJ;SULLIVAN, EV
通讯作者：
SULLIVAN, EV
在早期帕金森病中，空间延迟反应受损，而非物体延迟反应受损。
DOI：
10.1037//0894-4105.11.2.171
发表时间：
1997
期刊：
Neuropsychology.
影响因子：
--
作者：
Postle,BR;Jonides,J;Smith,EE;Corkin,S;Growdon,JH
通讯作者：
Growdon,JH