Spatial, but not object, delayed response is impaired in early Parkinson's disease.

Spatial, but not object, delayed response is impaired in early Parkinson's disease.
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在早期帕金森病中,空间延迟反应受损,而非物体延迟反应受损。

DOI:
10.1037//0894-4105.11.2.171
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发表时间:
1997
期刊:
Neuropsychology.
影响因子:
--
通讯作者:
Growdon,JH
Growdon,JH
中科院分区:
--
文献类型:
--
作者:
Postle,BR;Jonides,J;Smith,EE;Corkin,S;Growdon,JH

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作者假设,早期帕金森病(PD)的病理生理学可能选择性地靶向支持空间关系视觉工作记忆的结构,但保留支持对象特征性特征的工作记忆的结构相对完整。15名PD和15名正常对照参与者进行了视觉延迟反应测试,其中包括空间条件和(非空间)对象条件,等同于每个参与者测试的感知难度。刺激是在计算机屏幕上的不同位置呈现的不规则多边形。结果显示,PD的空间延迟反应的选择性损害,表明空间工作记忆的干扰不混淆的感觉处理困难。这种缺陷的选择性可能反映了PD早期影响尾状核的病理生理变化的局限性。(PsycInfo数据库记录(c)2016阿帕,保留所有权利)
The authors hypothesized that the pathophysiology of early Parkinson's disease (PD) may selectively target structures that support visual working memory for spatial relations but leave structures that support working memory for featural characteristics of objects relatively intact. Fifteen PD and 15 normal control participants took a visual delayed-response test with a spatial condition and a (nonspatial) object condition, equating the perceptual difficulty of the tests for each participant. The stimuli were irregular polygons presented at different locations on a computer screen. Results revealed a selective impairment of spatial delayed response in PD, indicating a disruption of spatial working memory unconfounded by sensory processing difficulties. The selectivity of this deficit may reflect the circumscribed nature of pathophysiological change affecting the caudate nucleus in early PD.(PsycINFO Database Record (c) 2016 APA, all rights reserved)
DOI: 10.1159/000116381
发表时间: 1989
期刊: European neurology
影响因子: 2.4
作者:
M. Piccirilli;P. D'alessandro;G. Finali;Luigi Piccinin;L. Agostini
通讯作者: M. Piccirilli;P. D'alessandro;G. Finali;Luigi Piccinin;L. Agostini
老年精神病学关键论文系列编辑:阿利斯泰尔·伯恩斯《老年痴呆症的定量测量与老年受试者脑灰质变化之间的关联》,G. Blessed、B. Tomlinson 和 M. Roth,英国精神病学杂志 (1968) 114、797–811。
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