Metrics from Wearable Devices as Candidate Predictors of Antibody Response Following Vaccination against COVID-19: Data from the Second TemPredict Study.
Metrics from Wearable Devices as Candidate Predictors of Antibody Response Following Vaccination against COVID-19: Data from the Second TemPredict Study.
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DOI：
10.3390/vaccines10020264
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发表时间：
2022-02-09
期刊：
影响因子：
7.8
通讯作者：
Hecht FM
中科院分区：
文献类型：
--
作者：
Mason AE;Kasl P;Hartogensis W;Natale JL;Dilchert S;Dasgupta S;Purawat S;Chowdhary A;Anglo C;Veasna D;Pandya LS;Fox LM;Puldon KY;Prather JG;Gupta A;Altintas I;Smarr BL;Hecht FM
接种 COVID-19 疫苗后，中和抗体反应（与免疫保护相关）存在显着差异，但有关这些反应预测因素的信息有限。我们研究了可穿戴设备收集的设备生成的生理指标摘要是否与疫苗接种后 SARS-CoV-2 受体结合域 (RBD) 的抗体水平相关，RBD 是现有 COVID-19 疫苗产生的中和抗体的目标。一千一百七十九名参与者佩戴了现成的可穿戴设备（Oura Ring），报告了 COVID-19 疫苗接种的日期，并在美国 COVID-19 疫苗接种期间完成了 SARS-CoV-2 RBD 抗体的测试。我们发现，在第二次 mRNA 注射（Moderna-NIAID 和 Pfizer-BioNTech）后的第二天晚上，真皮温度偏差和静息心率增加，心率变异性（交感神经系统激活的衡量标准）和深度睡眠的减少均与 RBD 抗体反应增强具有统计学显着相关性。在使用针对疫苗接种前基线期调整的指标的模型中，这些关联性更强。在多变量模型中，较大的温度偏差成为 RBD 抗体反应较大的最强独立预测因子。与某些其他疫苗的数据相比，我们没有发现疫苗接种周围的睡眠增加与抗体反应之间存在明显的关联。
There is significant variability in neutralizing antibody responses (which correlate with immune protection) after COVID-19 vaccination, but only limited information is available about predictors of these responses. We investigated whether device-generated summaries of physiological metrics collected by a wearable device correlated with post-vaccination levels of antibodies to the SARS-CoV-2 receptor-binding domain (RBD), the target of neutralizing antibodies generated by existing COVID-19 vaccines. One thousand, one hundred and seventy-nine participants wore an off-the-shelf wearable device (Oura Ring), reported dates of COVID-19 vaccinations, and completed testing for antibodies to the SARS-CoV-2 RBD during the U.S. COVID-19 vaccination rollout. We found that on the night immediately following the second mRNA injection (Moderna-NIAID and Pfizer-BioNTech) increases in dermal temperature deviation and resting heart rate, and decreases in heart rate variability (a measure of sympathetic nervous system activation) and deep sleep were each statistically significantly correlated with greater RBD antibody responses. These associations were stronger in models using metrics adjusted for the pre-vaccination baseline period. Greater temperature deviation emerged as the strongest independent predictor of greater RBD antibody responses in multivariable models. In contrast to data on certain other vaccines, we did not find clear associations between increased sleep surrounding vaccination and antibody responses.
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DOI：
10.1056/nejmoa2107659
发表时间：
2021-09-23
期刊：
The New England journal of medicine
影响因子：
--
作者：
Heath PT;Galiza EP;Baxter DN;Boffito M;Browne D;Burns F;Chadwick DR;Clark R;Cosgrove C;Galloway J;Goodman AL;Heer A;Higham A;Iyengar S;Jamal A;Jeanes C;Kalra PA;Kyriakidou C;McAuley DF;Meyrick A;Minassian AM;Minton J;Moore P;Munsoor I;Nicholls H;Osanlou O;Packham J;Pretswell CH;San Francisco Ramos A;Saralaya D;Sheridan RP;Smith R;Soiza RL;Swift PA;Thomson EC;Turner J;Viljoen ME;Albert G;Cho I;Dubovsky F;Glenn G;Rivers J;Robertson A;Smith K;Toback S;2019nCoV-302 Study Group
通讯作者：
2019nCoV-302 Study Group
DOI：
10.1177/1745691621989243
发表时间：
2021-03
期刊：
Perspectives on psychological science : a journal of the Association for Psychological Science
影响因子：
--
作者：
Madison AA;Shrout MR;Renna ME;Kiecolt-Glaser JK
通讯作者：
Kiecolt-Glaser JK
DOI：
10.1016/s1473-3099(21)00460-6
发表时间：
2022-01
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Antonelli M;Penfold RS;Merino J;Sudre CH;Molteni E;Berry S;Canas LS;Graham MS;Klaser K;Modat M;Murray B;Kerfoot E;Chen L;Deng J;Österdahl MF;Cheetham NJ;Drew DA;Nguyen LH;Pujol JC;Hu C;Selvachandran S;Polidori L;May A;Wolf J;Chan AT;Hammers A;Duncan EL;Spector TD;Ourselin S;Steves CJ
通讯作者：
Steves CJ
影响因子：
2.2
作者：
Hajduczok AG;DiJoseph KM;Bent B;Thorp AK;Mullholand JB;MacKay SA;Barik S;Coleman JJ;Paules CI;Tinsley A
通讯作者：
Tinsley A
影响因子：
168.9
作者：
Prymula, Roman;Siegrist, Claire-Anne;Schuerman, Lode
通讯作者：
Schuerman, Lode