Psychological and Behavioral Predictors of Vaccine Efficacy: Considerations for COVID-19.
Psychological and Behavioral Predictors of Vaccine Efficacy: Considerations for COVID-19.
复制标题
疫苗有效性的心理和行为预测因素：对COVID-19的考虑。
DOI：
10.1177/1745691621989243
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Kiecolt-Glaser JK
中科院分区：
文献类型：
--
作者：
Madison AA;Shrout MR;Renna ME;Kiecolt-Glaser JK
目前正在评估严重急性呼吸系统综合征冠状病毒2型（SARS-CoV-2）候选疫苗，目标是尽可能使接种疫苗的人获得免疫力。值得注意的是，疫苗的有效性不仅取决于疫苗，还取决于接种者的特征。在过去的30年里，一系列研究记录了心理因素对免疫系统疫苗反应的影响。强有力的证据表明，压力、抑郁、孤独和不良的健康行为会损害免疫系统对疫苗的反应，这种影响在老年人等弱势群体中可能最大。心理因素也与疫苗相关副作用的发生率和严重程度有关。这些发现已经推广到许多疫苗类型，因此可能与SARS-CoV-2疫苗有关。在这篇综述中，我们讨论了这些导致疫苗反应不良的心理和行为风险因素，它们与COVID-19大流行的相关性，以及有针对性的心理和行为干预措施，以提高疫苗效力并减少副作用。最近的数据表明，这些心理和行为风险因素在COVID-19大流行期间非常普遍，但干预研究表明，心理和行为干预可以提高疫苗效力。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine candidates are being evaluated, with the goal of conferring immunity on the highest percentage of people who receive the vaccine as possible. It is noteworthy that vaccine efficacy depends not only on the vaccine but also on characteristics of the vaccinated. Over the past 30 years, a series of studies has documented the impact of psychological factors on the immune system’s vaccine response. Robust evidence has demonstrated that stress, depression, loneliness, and poor health behaviors can impair the immune system’s response to vaccines, and this effect may be greatest in vulnerable groups such as the elderly. Psychological factors are also implicated in the prevalence and severity of vaccine-related side effects. These findings have generalized across many vaccine types and therefore may be relevant to the SARS-CoV-2 vaccine. In this review, we discuss these psychological and behavioral risk factors for poor vaccine responses, their relevance to the COVID-19 pandemic, as well as targeted psychological and behavioral interventions to boost vaccine efficacy and reduce side effects. Recent data suggest these psychological and behavioral risk factors are highly prevalent during the COVID-19 pandemic, but intervention research suggests that psychological and behavioral interventions can increase vaccine efficacy.
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影响因子：
3.3
作者：
Cohen, S;Miller, GE;Rabin, BS
通讯作者：
Rabin, BS
影响因子：
15.1
作者：
Edwards, Kate M.;Burns, Victoria E.;Ring, Christopher
通讯作者：
Ring, Christopher
影响因子：
3.7
作者：
CARSTENSEN, LL
通讯作者：
CARSTENSEN, LL
影响因子：
3.7
作者：
Elmer, Timon;Mepham, Kieran;Stadtfeld, Christoph
通讯作者：
Stadtfeld, Christoph
DOI：
10.1016/j.bbih.2019.100009
发表时间：
2020-01-01
期刊：
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
影响因子：
--
作者：
Bohn-Goldbaum, Erika;Pascoe, April;Edwards, Kate M.
通讯作者：
Edwards, Kate M.