The Hitchhiker's guide to Hi-C analysis: practical guidelines.
The Hitchhiker's guide to Hi-C analysis: practical guidelines.
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DOI:
10.1016/j.ymeth.2014.10.031
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发表时间:
2015-01-15
期刊:
影响因子:
4.8
通讯作者:
Kaplan, Noam
中科院分区:
文献类型:
--
作者:
Lajoie, Bryan R.;Dekker, Job;Kaplan, Noam
Over the last decade, development and application of a set of molecular genomic approaches based on the chromosome conformation capture method (3C), combined with increasingly powerful imaging approaches, have enabled high resolution and genome-wide analysis of the spatial organization of chromosomes. The aim of this paper is to provide guidelines for analyzing and interpreting data obtained with genome-wide 3C methods such as Hi-C and 3C-seq that rely on deep sequencing to detect and quantify pairwise chromatin interactions genome-wide.
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