Percutaneous catheter and guidewire fragmentation with local administration of recombinant tissue plasminogen activator as a treatment for massive pulmonary embolism
Percutaneous catheter and guidewire fragmentation with local administration of recombinant tissue plasminogen activator as a treatment for massive pulmonary embolism
复制标题
经皮导管和导丝断裂并局部给予重组组织纤溶酶原激活剂治疗大面积肺栓塞
DOI：
10.1007/s003300050776
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发表时间：
1999
影响因子：
5.9
通讯作者：
M. Molloy
中科院分区：
文献类型：
--
作者：
J. Murphy;N. Mulvihill;D. Mulcahy;B. Foley;P. Smiddy;M. Molloy
Abstract. The purpose of this article is to report four patients with massive pulmonary embolism treated with percutaneous catheter and guidewire fragmentation and local administration of recombinant tissue plasminogen activator (r-TPA). Four patients with massive pulmonary embolism initially underwent pulmonary angiography. Thrombus fragmentation was performed with both standard angiographic guidewires and catheters followed by local infusion of 41–200 mg of r-TPA. Pulmonary angiography was repeated after treatment. All patients survived with improvement in their clinical status and eventual discharge from hospital. Angiography in all patients post treatment demonstrated improvement in pulmonary perfusion (mean Miller score before treatment 22.5; mean Miller score after treatment 5.75). No patient had a significant complication. Mechanical fragmentation of the thrombus followed by local infusion of r-TPA was an effective treatment for massive pulmonary embolism in these four patients with no significant complications.
影响因子：
9.6
作者：
LILIENFELD, DE;CHAN, E;MARSH, G
通讯作者：
MARSH, G