Non-invasive methods to evaluate liver fibrosis in patients with non-alcoholic fatty liver disease.
Non-invasive methods to evaluate liver fibrosis in patients with non-alcoholic fatty liver disease.
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非酒精性脂肪肝患者肝纤维化的非侵入性评估方法
DOI：
10.3389/fphys.2022.1046497
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发表时间：
2022
影响因子：
4
通讯作者：
Lu, Xiaojie
中科院分区：
文献类型：
--
作者：
Wang, Jincheng;Qin, Tao;Sun, Jinyu;Li, Shiwu;Cao, Lihua;Lu, Xiaojie
非酒精性脂肪性肝病(NAFLD)是一种与胰岛素抵抗和代谢综合征密切相关的慢性肝病，已成为发达国家最常见的肝病。NAFLD包括三种情况的完整病理过程：脂肪变性、非酒精性脂肪性肝炎，最后是肝硬变。随着NAFLD的进展，随着纤维化的发展，症状将变得越来越严重。因此，评估NAFLD患者的纤维化分期是至关重要的。肝活检目前被认为是分期纤维化的黄金标准。然而，由于肝活检的局限性，非侵入性替代方案在NAFLD患者中得到了广泛的研究和验证。与其他有创方法相比，非侵入性方法具有安全性高、操作方便等优点。该综述介绍了非侵入性方法，总结了它们的优点和局限性，并评估了它们对NAFLD诱导的纤维化的诊断性能。
Non-alcoholic Fatty Liver Disease (NAFLD) is a chronic liver disease that is strongly related to insulin resistance and metabolic syndrome, and it has become the most common liver disorder in developed countries. NAFLD embraces the full pathological process of three conditions: steatosis, non-alcoholic steatohepatitis, and finally, cirrhosis. As NAFLD progresses, symptoms will become increasingly severe as fibrosis develops. Therefore, evaluating the fibrosis stage is crucial for patients with NAFLD. A liver biopsy is currently considered the gold standard for staging fibrosis. However, due to the limitations of liver biopsy, non-invasive alternatives were extensively studied and validated in patients with NAFLD. The advantages of non-invasive methods include their high safety and convenience compared with other invasive approaches. This review introduces the non-invasive methods, summarizes their benefits and limitations, and assesses their diagnostic performance for NAFLD-induced fibrosis.
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影响因子：
4.4
作者：
Bonekamp, Susanne;Tang, An;Mashhood, Arian;Wolfson, Tanya;Changchien, Christopher;Middleton, Michael S.;Clark, Lisa;Gamst, Anthony;Loomba, Rohit;Sirlin, Claude B.
通讯作者：
Sirlin, Claude B.
影响因子：
24.5
作者：
Angelini, Giulia;Panunzi, Simona;Castagneto-Gissey, Lidia;Pellicano, Francesca;De Gaetano, Andrea;Pompili, Maurizio;Riccardi, Laura;Garcovich, Matteo;Raffaelli, Marco;Ciccoritti, Luigi;Verrastro, Ornella;Russo, Maria Francesca;Vecchio, Fabio Maria;Casella, Giovanni;Casella-Mariolo, James;Papa, Luigi;Marini, Pier Luigi;Rubino, Francesco;le Roux, Carel W.;Bornstein, Stefan;Mingrone, Geltrude
通讯作者：
Mingrone, Geltrude
DOI：
10.1111/j.1440-1746.2011.06774.x
发表时间：
2011-10-01
影响因子：
4.1
作者：
Adams, Leon A.;George, Jacob;Jeffrey, Gary P.
通讯作者：
Jeffrey, Gary P.
影响因子：
25.7
作者：
Cales, Paul;Laine, Fabrice;Lunel, Francoise
通讯作者：
Lunel, Francoise
影响因子：
6.6
作者：
Chan, Wah-Kheong;Mustapha, Nik Raihan Nik;Mahadeva, Sanjiv
通讯作者：
Mahadeva, Sanjiv