Dietary compliance in a randomized double-blind infant feeding trial during infancy aiming at prevention of type 1 diabetes.
Dietary compliance in a randomized double-blind infant feeding trial during infancy aiming at prevention of type 1 diabetes.
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DOI：
10.1002/fsn3.2389
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发表时间：
2021-08
影响因子：
3.9
通讯作者：
TRIGR Investigators
中科院分区：
文献类型：
--
作者：
Virtanen SM;Cuthbertson D;Nucci AM;Hyytinen M;Ormisson A;Salonen M;Turrini T;Cummings EA;Bradley B;Tanner-Blasiar M;Becker DJ;Åkerblom HK;Savilahti E;Krischer JP;Knip M;TRIGR Investigators
减少遗传风险中 IDDM 的国际试验 (TRIGR) 测试了以下假设：与普通牛奶为基础的婴儿配方奶粉相比，深度水解酪蛋白配方是否能降低 1 型糖尿病的风险。我们从研究配方奶摄入量、非推荐食物喂养以及反映牛奶蛋白摄入量的血清牛奶抗体浓度等方面描述了试验中的饮食依从性，研究对象是 2,159 名符合条件的新生儿，这些婴儿的生物学一级亲属患有 1 型糖尿病，并且具有 HLA 赋予的 1 型糖尿病易感性。参与研究的婴儿在中位年龄 15 天时开始接受配方奶粉喂养，中位使用研究配方奶粉的持续时间为 63 天。在干预期间，80% 的婴儿接受了研究配方奶粉。其中，57% 的人接受了至少 2 个月的研究配方奶粉。平均每个婴儿使用 45.5 升研究配方奶粉。只有 13% 的人在 6 个月大时接受过非推荐的食物。干预组和对照组的饮食依从性相似。报告的家庭牛奶消耗量与测量的血清酪蛋白 IgA 和 IgG 抗体浓度非常吻合。总之，在这项随机婴儿喂养试验中观察到良好的依从性。不同地区的依从性存在差异，母乳喂养时间较长的婴儿接触研究配方奶粉的时间较短。婴儿喂养试验中的高饮食依从性对于准确解释研究结果是必要的。减少遗传风险中 IDDM 的国际试验 (TRIGR) 测试了以下假设：与普通牛奶为基础的婴儿配方奶粉相比，深度水解酪蛋白配方是否能降低 1 型糖尿病的风险。我们描述了试验中良好的饮食依从性，包括研究配方奶粉喂养、非推荐食物喂养以及反映牛奶蛋白摄入量的血清牛奶抗体浓度，这些新生儿的生物学一级亲属患有 1 型糖尿病，且 HLA 赋予 1 型糖尿病易感性。
The international Trial to Reduce IDDM in the Genetically at Risk (TRIGR) tested the hypothesis whether extensively hydrolyzed casein‐based versus regular cow's milk‐based infant formula reduces the risk of type 1 diabetes. We describe dietary compliance in the trial in terms of study formula intake, feeding of nonrecommended foods, and serum cow's milk antibody concentration reflecting intake of cow's milk protein among 2,159 eligible newborn infants with a biological first‐degree relative affected by type 1 diabetes and with HLA‐conferred susceptibility to type 1 diabetes. The participating infants were introduced to the study formula feeding at the median age of 15 days with a median duration of study formula use of 63 days. During the intervention, 80% of the infants received study formula. Of these, 57% received study formula for at least 2 months. On average, 45.5 l of study formula were used per infant. Only 13% of the population had received a nonrecommended food by the age of 6 months. The dietary compliance was similar in the intervention and control arm. The reported cow's milk consumption by the families matched very well with measured serum casein IgA and IgG antibody concentration. To conclude, good compliance was observed in this randomized infant feeding trial. Compliance varied between the regions and those infants who were breastfed for a longer period of time had a shorter exposure to the study formula. High dietary compliance in infant feeding trial is necessary to allow accurate interpretation of study results. The international Trial to Reduce IDDM in the Genetically at Risk (TRIGR) tested the hypothesis whether extensively hydrolyzed casein‐based versus regular cow's milk‐based infant formula reduces the risk of type 1 diabetes. We describe good dietary compliance in the trial in terms of study formula feeding, feeding of non‐recommended foods, and serum cow's milk antibody concentration reflecting intake of cow's milk protein among 2,159 eligible newborn infants with a biological first degree relative affected by type 1 diabetes and with HLA‐conferred susceptibility to type 1 diabetes.
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影响因子：
14.2
作者：
ZEIGER, RS;HELLER, S;SCHATZ, M
通讯作者：
SCHATZ, M
影响因子：
4.4
作者：
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通讯作者：
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8.2
作者：
Patterson, Christopher C.;Harjutsalo, Valma;Green, Anders
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影响因子：
120.7
作者：
Knip, Mikael;Akerblom, Hans K.;Wasikowa, Renata
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1型糖尿病母亲的母乳喂养模式：婴儿喂养试验的结果。
影响因子：
8
作者：
Sorkio, Susa;Cuthbertson, David;Barlund, Sonja;Reunanen, Antti;Nucci, Anita M.;Berseth, Carol L.;Koski, Katriina;Ormisson, Anne;Savilahti, Erkki;Uusitalo, Ulla;Ludvigsson, Johnny;Becker, Dorothy J.;Dupre, John;Krischer, Jeffrey P.;Knip, Mikael;Akerblom, Hans K.;Virtanen, Suvi M.
通讯作者：
Virtanen, Suvi M.