A Similar Speciation Process Relying on Cellular Stochasticity in Microbial and Cancer Cell Populations.
A Similar Speciation Process Relying on Cellular Stochasticity in Microbial and Cancer Cell Populations.
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DOI：
10.1016/j.isci.2020.101531
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发表时间：
2020-09-25
期刊：
影响因子：
5.8
通讯作者：
Thomas F
中科院分区：
文献类型：
--
作者：
Capp JP;Thomas F
微生物和癌细胞之间的相似性近年来被注意到，并作为癌症返祖理论的基础。癌细胞将依赖于在后生动物细胞中被抑制的祖先“遗传程序”的重新激活。在这里，我们认为癌细胞与单细胞生物的相似之处在于它们利用细胞的随机性来产生细胞特化和最大化增殖。事实上，在正常分化的后生动物细胞中发现的低随机性、特化和静止之间的关系在癌症中消失了。相反，低随机性和特化与癌细胞的高增殖有关，因为我们观察到微生物群体中的“特化”细胞充分利用营养资源来最大化增殖。因此，我们提出了一个模型，其中癌症表型的出现可能仅仅是由于适应和基于细胞随机性初始增加的物种形成过程。生态学;进化生物学;癌症
Similarities between microbial and cancer cells were noticed in recent years and serve as a basis for an atavism theory of cancer. Cancer cells would rely on the reactivation of an ancestral “genetic program” that would have been repressed in metazoan cells. Here we argue that cancer cells resemble unicellular organisms mainly in their similar way to exploit cellular stochasticity to produce cell specialization and maximize proliferation. Indeed, the relationship between low stochasticity, specialization, and quiescence found in normal differentiated metazoan cells is lost in cancer. On the contrary, low stochasticity and specialization are associated with high proliferation among cancer cells, as it is observed for the “specialist” cells in microbial populations that fully exploit nutritional resources to maximize proliferation. Thus, we propose a model where the appearance of cancer phenotypes can be solely due to an adaptation and a speciation process based on initial increase in cellular stochasticity. Ecology; Evolutionary Biology; Cancer
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影响因子：
2
作者：
Davies PC;Lineweaver CH
通讯作者：
Lineweaver CH
DOI：
10.1073/pnas.1102454108
发表时间：
2011-05-10
影响因子：
11.1
作者：
Chaffer, Christine L.;Brueckmann, Ines;Weinberg, Robert A.
通讯作者：
Weinberg, Robert A.
影响因子：
7.7
作者：
Featherstone, Karen;Hey, Kirsty;Davis, Julian R. E.
通讯作者：
Davis, Julian R. E.
DOI：
10.1016/j.cub.2016.03.010
发表时间：
2016-05-09
期刊：
Current biology : CB
影响因子：
--
作者：
Cerulus B;New AM;Pougach K;Verstrepen KJ
通讯作者：
Verstrepen KJ
DOI：
10.1126/science.aal2380
发表时间：
2017-07-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Flavahan WA;Gaskell E;Bernstein BE
通讯作者：
Bernstein BE