Human papillomavirus-related disease in men: not just a women's issue.
Human papillomavirus-related disease in men: not just a women's issue.
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DOI：
10.1016/j.jadohealth.2010.01.010
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发表时间：
2010-04
影响因子：
7.6
通讯作者：
Palefsky, Joel M.
中科院分区：
文献类型：
--
作者：
Palefsky, Joel M.
与人乳头瘤病毒（HPV）感染有关的最常见的死亡原因是宫颈癌。然而，男性HPV感染也是一个重要的问题，无论是男性的疾病负担还是传播给女性的风险。HPV与男性的多种癌症有关，包括肛门癌和阴茎癌和口腔癌的子集。与HPV相关的肛门和口腔癌的发病率在一般人群中正在增加，并且在由于HIV感染而免疫功能低下的个体中增长得更快。阴茎HPV感染在异性恋男性中非常常见，并且在各种年龄段都很高。同样，肛门HPV感染和肛门上皮内瘤变在HIV阴性和HIV阳性的男男性行为者中在很大的年龄范围内都很常见。在男性中具有临床重要性的其他HPV相关疾病包括尖锐湿疣（生殖器疣）和复发性呼吸道乳头状瘤病。四价HPV疫苗已被证明在预防女性生殖器疣以及宫颈癌、外阴癌和阴道癌前病变方面非常有效。此外，最近的中期数据显示，四价HPV疫苗在减少年轻男性外生殖器病变方面非常有效。虽然HPV疫苗在男性中的保护效果尚未完全确定-等待公共政策讨论和成本效益研究的结果-可能有一个强有力的理由为男孩接种疫苗，类似于女孩，在他们有限制或没有先前的性活动的早期年龄。
The most common cause of mortality related to human papillomavirus (HPV) infection is cervical cancer. However, male HPV infection is also an important concern, both for the disease burden in men and for the risk of transmission to women. HPV is associated with a variety of cancers in men, including anal cancer and a subset of penile and oral cancers. The incidence of anal and oral cancers related to HPV is increasing in the general population and is growing even faster among individuals who are immunocompromised due to HIV infection. Penile HPV infection is very common among heterosexual men and remains high throughout a wide range of ages. Likewise, anal HPV infection and anal intraepithelial neoplasia are very common throughout a wide range of ages in both HIV-negative and HIV-positive men who have sex with men. Other HPV-related diseases of clinical importance in men include condylomata acuminata (genital warts) and recurrent respiratory papillomatosis. The quadrivalent HPV vaccine has been shown to be highly efficacious in the prevention of genital warts in women and precancerous lesions of the cervix, vulva, and vagina. In addition, recent interim data have shown that the quadrivalent HPV vaccine is highly effective in reducing external genital lesions in young men. Although the protective efficacy of HPV vaccination in males has not yet been fully established—pending the outcome of public policy discussions and cost-efficacy studies—there may be a strong rationale for vaccinating boys, similar to girls, at an early age when they have had limited or no prior sexual activity.
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肛门人乳头瘤病毒感染与与男性发生性关系的男性中的艾滋病毒获取有关。
DOI：
10.1097/qad.0b013e32832b4449
发表时间：
2009-06-01
期刊：
AIDS (London, England)
影响因子：
--
作者：
Chin-Hong PV;Husnik M;Cranston RD;Colfax G;Buchbinder S;Da Costa M;Darragh T;Jones D;Judson F;Koblin B;Mayer KH;Palefsky JM
通讯作者：
Palefsky JM
DOI：
10.1097/qai.0b013e31817aebfe
发表时间：
2008-08-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
D'Souza G;Wiley DJ;Li X;Chmiel JS;Margolick JB;Cranston RD;Jacobson LP
通讯作者：
Jacobson LP
影响因子：
6.4
作者：
D'Souza, Gypsyamber;Fakhry, Carole;Gillison, Maura L.
通讯作者：
Gillison, Maura L.
影响因子：
6.4
作者：
Castellsague, X;Ghaffari, A;Shah, KV
通讯作者：
Shah, KV
影响因子：
39.2
作者：
Chin-Hong, Peter V.;Berry, J. Michael;Palefsky, Joel M.
通讯作者：
Palefsky, Joel M.