DNA Methylation: A Target in Neuropathic Pain.
DNA Methylation: A Target in Neuropathic Pain.
复制标题
DNA 甲基化：神经性疼痛的靶点
DOI：
10.3389/fmed.2022.879902
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发表时间：
2022
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
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作者：
Neuropathic pain (NP), caused by an injury or a disease affecting the somatosensory nervous system of the central and peripheral nervous systems, has become a global health concern. Recent studies have demonstrated that epigenetic mechanisms are among those that underlie NP; thus, elucidating the molecular mechanism of DNA methylation is crucial to discovering new therapeutic methods for NP. In this review, we first briefly discuss DNA methylation, demethylation, and the associated key enzymes, such as methylases and demethylases. We then discuss the relationship between NP and DNA methylation, focusing on DNA methyltransferases including methyl-CpG-binding domain (MBD) family proteins and ten-eleven translocation (TET) enzymes. Based on experimental results of neuralgia in animal models, the mechanism of DNA methylation-related neuralgia is summarized, and useful targets for early drug intervention in NP are discussed.
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影响因子：
81.5
作者：
Colloca, Luana;Ludman, Taylor;Raja, Srinivasa N.
通讯作者：
Raja, Srinivasa N.
影响因子：
2.8
作者：
Holliday, R
通讯作者：
Holliday, R
DOI：
10.1038/nrg2485
发表时间：
2009-01
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
6.4
作者：
Cardoso, Ana L.;Guedes, Joana R.;Pedroso de Lima, Maria C.
通讯作者：
Pedroso de Lima, Maria C.
影响因子：
0.9
作者：
Chamessian AG;Qadri YJ;Cummins M;Hendrickson M;Berta T;Buchheit T;Van de Ven T
通讯作者：
Van de Ven T