A noninvasive handheld assistive device to accommodate essential tremor: a pilot study.
A noninvasive handheld assistive device to accommodate essential tremor: a pilot study.
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DOI：
10.1002/mds.25796
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发表时间：
2014-05
影响因子：
8.6
通讯作者：
Chou, Kelvin L.
中科院分区：
文献类型：
--
作者：
Pathak, Anupam;Redmond, John A.;Allen, Michael;Chou, Kelvin L.
我们探讨了使用主动震颤消除（ACT）技术的非侵入性手持设备是否可以稳定特发性震颤（ET）患者中震颤诱导的勺子运动。15例ET受试者（9例男性/6例女性）在ACT器械打开和关闭的情况下执行了3项任务。采用Fahn-Tolosa-Marin震颤评定量表（TRS）评定震颤严重程度。采用临床总体印象量表（CGI-S）对受试者的主观改善进行评定。震颤幅度测量使用设备嵌入式加速度计在11名受试者。在所有3项任务中，ACT开启（与关闭相比）时TRS评分均有所改善：保持（1.00 ± 0.76 vs. 0.27 ± 0.70，p = 0.016）、进食（1.47 ± 1.06 vs. 0.13 ± 0.64，p = 0.001）和转移（1.33 ± 0.82 vs. 0.27 ± 0.59，p = 0.001）。CGI-S随着进食和转移而改善，但不是保持任务。加速度计测量显示，ACT设备的震颤减少了71 - 76%。这种非侵入性的手持式ACT设备可以减少ET患者进食和转移任务时的震颤幅度和严重程度。
We explored whether a non-invasive, handheld device using Active Cancellation of Tremor (ACT) technology could stabilize tremor-induced motion of a spoon in individuals with essential tremor (ET). Fifteen ET subjects (9M/6F) performed 3 tasks with the ACT device turned on and off. Tremor severity was rated with the Fahn-Tolosa-Marin Tremor Rating Scale (TRS). Subjective improvement was rated by subjects with the Clinical Global Impression Scale (CGI-S). Tremor amplitude was measured using device-embedded accelerometers in 11 subjects. TRS scores improved with ACT on (versus off) in all 3 tasks: holding (1.00±0.76 vs. 0.27±0.70, p=0.016), eating (1.47±1.06 vs. 0.13±0.64, p=0.001) and transferring (1.33±0.82 vs. 0.27±0.59, p=0.001). CGI-S improved with eating and transferring, but not the holding task. Accelerometer measurements demonstrated 71-76% reduction in tremor with ACT device on. This non-invasive, handheld ACT device can reduce tremor amplitude and severity for eating and transferring tasks in individuals with ET.
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