Review of Atypical and Anaplastic Meningiomas: Classification, Molecular Biology, and Management.
Review of Atypical and Anaplastic Meningiomas: Classification, Molecular Biology, and Management.
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DOI：
10.3389/fonc.2020.565582
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发表时间：
2020
影响因子：
4.7
通讯作者：
Boling W
中科院分区：
文献类型：
--
作者：
Wilson TA;Huang L;Ramanathan D;Lopez-Gonzalez M;Pillai P;De Los Reyes K;Kumal M;Boling W
虽然大多数脑膜瘤是生长缓慢和良性的，但不典型和间变性脑膜瘤表现为侵袭性，有复发的倾向。对于间变性脑膜瘤和部分切除的非典型脑膜瘤，标准治疗包括手术切除后辅助性放射治疗；然而，对于未完全切除的非典型脑膜瘤，辅助放射治疗的作用仍有争议。尽管进行了最大限度的治疗，非典型性和间变性脑膜瘤仍有很强的复发倾向。随着时间的推移，随着时间的推移，复发的肿瘤会积累突变，表现得更具侵袭性，往往变得难以治愈或不再适用于进一步的手术切除或放射治疗。一旦标准选择耗尽，化疗和其他药物治疗就可以作为抢救治疗；然而，这些药物的疗效仍然有限。本文讨论了脑膜瘤的危险因素、分类和分子生物学，以及目前的治疗策略、新的治疗方法和未来的研究方向。
Although the majority of meningiomas are slow-growing and benign, atypical and anaplastic meningiomas behave aggressively with a penchant for recurrence. Standard of care includes surgical resection followed by adjuvant radiation in anaplastic and partially resected atypical meningiomas; however, the role of adjuvant radiation for incompletely resected atypical meningiomas remains debated. Despite maximum treatment, atypical, and anaplastic meningiomas have a strong proclivity for recurrence. Accumulating mutations over time, recurrent tumors behave more aggressively and often become refractory or no longer amenable to further surgical resection or radiation. Chemotherapy and other medical therapies are available as salvage treatment once standard options are exhausted; however, efficacy of these agents remains limited. This review discusses the risk factors, classification, and molecular biology of meningiomas as well as the current management strategies, novel therapeutic approaches, and future directions for managing atypical and anaplastic meningiomas.
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