Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines.
Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines.
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DOI：
10.1126/science.abq0203
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发表时间：
2022-08-19
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引起关注的严重急性呼吸系统综合征冠状病毒2型（SARS-CoV-2）Omicron变异体包括几个亚系，BA.2和BA.2.12.1取代了以前占主导地位的BA.1，BA.4和BA.5在世界范围内的流行率正在上升。我们发现，大量的Omicron亚系穗突变导致增强血管紧张素转换酶2（ACE 2）的结合，降低融合性，并严重抑制血浆中和活性引起的感染或7个临床疫苗相对于祖先病毒。在所有评价的疫苗中，基于武汉-Hu-1刺突序列给予同源或异源加强剂显著增加了针对BA.1、BA.2、BA.2.12.1、BA.4和BA.5的中和抗体滴度和宽度。我们的数据表明，虽然Omicron亚系逃避多克隆中和抗体反应引起的初级疫苗系列，疫苗加强剂可以提供足够的保护，对Omicron诱导的严重疾病。严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）的Omicron毒株于2021年首次被发现，目前在地球仪中占主导地位。Bowen等人表明，Omicron亚系BA.1、BA.2、BA.2.12和BA.4/5对人类细胞上ACE 2受体的亲和力增加，但细胞-细胞融合减少。他们使用假病毒来测量先前感染或接种过七种疫苗之一的个体血浆中对Omicron亚系的中和活性，这些疫苗都是基于武汉-胡-1变体。对于接种者和康复者来说，中和活性都受到严重抑制。用最初使用的相同疫苗或其他基于武汉-胡-1的疫苗之一加强，增加了所有评估疫苗的中和作用。越来越普遍的Omicron BA.4/BA.5亚系表现出增强的受体结合和逃避中和抗体。
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern comprises several sublineages, with BA.2 and BA.2.12.1 having replaced the previously dominant BA.1 and with BA.4 and BA.5 increasing in prevalence worldwide. We show that the large number of Omicron sublineage spike mutations leads to enhanced angiotensin-converting enzyme 2 (ACE2) binding, reduced fusogenicity, and severe dampening of plasma neutralizing activity elicited by infection or seven clinical vaccines relative to the ancestral virus. Administration of a homologous or heterologous booster based on the Wuhan-Hu-1 spike sequence markedly increased neutralizing antibody titers and breadth against BA.1, BA.2, BA.2.12.1, BA.4, and BA.5 across all vaccines evaluated. Our data suggest that although Omicron sublineages evade polyclonal neutralizing antibody responses elicited by primary vaccine series, vaccine boosters may provide sufficient protection against Omicron-induced severe disease. The Omicron strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first detected in 2021 and is now dominant across the globe. Bowen et al. show that the Omicron sublineages BA.1, BA.2, BA.2.12, and BA.4/5 have increased affinity for the ACE2 receptor on human cells, but show decreased cell-cell fusion. They used pseudovirus to measure neutralizing activity against Omicron sublineages in plasma from individuals who were previously infected or vaccinated with one of seven vaccines, all based on the Wuhan-Hu-1 variant. For both vaccinees and convalescents, there was severe dampening of neutralizing activity. Boosting with either the same vaccine used initially or one of the other Wuhan-Hu-1–based vaccines increased neutralization across all vaccines evaluated. —VV The increasingly prevalent Omicron BA.4/BA.5 sublineages exhibit enhanced receptor binding and escape from neutralizing antibodies.
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DOI：
10.1056/nejmoa2119451
发表时间：
2022-04-21
期刊：
The New England journal of medicine
影响因子：
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作者：
Andrews N;Stowe J;Kirsebom F;Toffa S;Rickeard T;Gallagher E;Gower C;Kall M;Groves N;O'Connell AM;Simons D;Blomquist PB;Zaidi A;Nash S;Iwani Binti Abdul Aziz N;Thelwall S;Dabrera G;Myers R;Amirthalingam G;Gharbia S;Barrett JC;Elson R;Ladhani SN;Ferguson N;Zambon M;Campbell CNJ;Brown K;Hopkins S;Chand M;Ramsay M;Lopez Bernal J
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10.1016/j.xcrm.2021.100230
发表时间：
2021-04-20
期刊：
Cell reports. Medicine
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Hassan AO;Feldmann F;Zhao H;Curiel DT;Okumura A;Tang-Huau TL;Case JB;Meade-White K;Callison J;Chen RE;Lovaglio J;Hanley PW;Scott DP;Fremont DH;Feldmann H;Diamond MS
通讯作者：
Diamond MS
影响因子：
56.9
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Cai, Yongfei;Zhang, Jun;Chen, Bing
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Chen, Bing
DOI：
10.1101/2021.08.09.21261290
发表时间：
2022-01-07
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
Gilbert, Peter B;Montefiori, David C;Koup, Richard A
通讯作者：
Koup, Richard A
影响因子：
17.1
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Collier AY;Brown CM;McMahan KA;Yu J;Liu J;Jacob-Dolan C;Chandrashekar A;Tierney D;Ansel JL;Rowe M;Sellers D;Ahmad K;Aguayo R;Anioke T;Gardner S;Siamatu M;Bermudez-Rivera L;Hacker MR;Madoff LC;Barouch DH
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