Functional Brain Connectivity Prior to the COVID-19 Outbreak Moderates the Effects of Coping and Perceived Stress on Mental Health Changes: A First Year of COVID-19 Pandemic Follow-up Study.
Functional Brain Connectivity Prior to the COVID-19 Outbreak Moderates the Effects of Coping and Perceived Stress on Mental Health Changes: A First Year of COVID-19 Pandemic Follow-up Study.
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DOI：
10.1016/j.bpsc.2022.08.005
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发表时间：
2023-03
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2019冠状病毒病大流行提供了一个独特的机会来调查全球重大不利情况的心理影响。我们的目的是在一项纵向前瞻性研究中，研究与抗疫能力个体间差异相关的人口统计学、心理学和神经生物学因素。我们纳入了来自巴塞罗那脑健康倡议队列的2023名健康参与者（年龄：54.32 ± 7.18岁，65.69%为女性）。根据大流行前和大流行期间收集的数据，使用线性混合模型来描述焦虑和抑郁症状的变化。在大流行期间，获得了评估感知压力和应对策略的个体差异的心理变量。此外，在一个有大流行前静息态功能磁共振成像的子样本（n = 433，年龄53.02 ± 7.04岁，46.88%为女性）中，计算了网络的系统隔离。拟合多变量线性模型，以检验COVID-19相关的心理健康变化与人口统计学、心理特征和大脑网络状态之间的关联。整个样本显示，在大流行爆发后，焦虑和抑郁症状普遍增加，年龄和性别都是独立的预测因素。应对策略减弱了知觉压力对心理健康的影响。额顶控制和默认模式网络的系统分离被发现调节知觉压力对心理健康的影响。在未来类似不良事件期间，针对促进个体水平心理健康的预防策略应考虑对社会人口和心理因素及其与神经生物学底物的相互作用进行干预。
The COVID-19 pandemic provides a unique opportunity to investigate the psychological impact of a global major adverse situation. Our aim was to examine, in a longitudinal prospective study, the demographic, psychological, and neurobiological factors associated with interindividual differences in resilience to the mental health impact of the pandemic. We included 2023 healthy participants (age: 54.32 ± 7.18 years, 65.69% female) from the Barcelona Brain Health Initiative cohort. A linear mixed model was used to characterize the change in anxiety and depression symptoms based on data collected both pre-pandemic and during the pandemic. During the pandemic, psychological variables assessing individual differences in perceived stress and coping strategies were obtained. In addition, in a subsample (n = 433, age 53.02 ± 7.04 years, 46.88% female) with pre-pandemic resting-state functional magnetic resonance imaging available, the system segregation of networks was calculated. Multivariate linear models were fitted to test associations between COVID-19–related changes in mental health and demographics, psychological features, and brain network status. The whole sample showed a general increase in anxiety and depressive symptoms after the pandemic onset, and both age and sex were independent predictors. Coping strategies attenuated the impact of perceived stress on mental health. The system segregation of the frontoparietal control and default mode networks were found to modulate the impact of perceived stress on mental health. Preventive strategies targeting the promotion of mental health at the individual level during similar adverse events in the future should consider intervening on sociodemographic and psychological factors as well as their interplay with neurobiological substrates.
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