Structure, dynamics and function of nuclear pore complexes.
Structure, dynamics and function of nuclear pore complexes.
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DOI：
10.1016/j.tcb.2008.07.009
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发表时间：
2008-10
影响因子：
19
通讯作者：
Hetzer, Martin W.
中科院分区：
文献类型：
--
作者：
D'Angelo, Maximiliano A.;Hetzer, Martin W.
Nuclear pore complexes are large aqueous channels that penetrate the nuclear envelope, connecting the nuclear interior with the cytoplasm. Until recently, these macromolecular complexes were viewed as static structures whose only function was to control the molecular trafficking between the two compartments. It has now become evident that this simplistic scenario is inaccurate and that nuclear pore complexes are highly dynamic multiprotein assemblies involved in diverse cellular processes ranging from the organization of the cytoskeleton to gene expression. In this review, we will discuss the most recent developments in the nuclear pore complex field, focusing in the assembly, disassembly, maintenance and function of this macromolecular structure.
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