Dietary peptides induce satiety via cholecystokinin-A and peripheral opioid receptors in rats.
Dietary peptides induce satiety via cholecystokinin-A and peripheral opioid receptors in rats.
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膳食肽通过胆囊收缩素-A 和外周阿片受体诱导大鼠产生饱腹感。
DOI：
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
G. Anderson
中科院分区：
文献类型：
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作者：
Jelena Pupovac;G. Anderson
我们假设，蛋白质的消化产生了从肠道发出几个饱腹感信号的多肽，而产生的信号将取决于蛋白质来源。研究外周阿片和胆囊收缩素(CCK)-A受体的作用。大鼠灌胃给予酪蛋白、大豆蛋白、酪蛋白和大豆水解物(蛋白质0.5g/4mL水)。阿片受体拮抗剂甲碘化纳洛酮(1.0 mg/kg)在水解物预负荷的同时、酪蛋白预负荷后25min和大豆蛋白预负荷后55min同时给药，可增加大鼠的摄食量。CCK-A受体拮抗剂Devazepide(逆转蛋白质诱导的食物摄取抑制)在三种大豆水解物预负荷前60min以0.25 mg/kg的剂量给药，也能阻断食物摄取的抑制，但相互作用的强度和持续时间取决于制剂。当两种受体拮抗剂都与大豆或酪蛋白预加载时，它们的作用是相加的。我们得出结论，消化产生的多肽通过阿片受体和CCK-A受体的独立激活来促进饱足感。
We hypothesized that the digestion of proteins gives rise to peptides that initiate several satiety signals from the gut, and that the signals arising will be dependent on the protein source. The role of peripheral opioid and cholecystokinin (CCK)-A receptors was investigated. Casein, soy protein, and casein and soy hydrolysates were administered to rats by gavage (0.5 g protein/4 mL water). Food intake was measured over 2 h. The opioid receptor antagonist, naloxone methiodide (1.0 mg/kg) given intraperitoneally (i.p.), increased food intake when given at the same time as the hydrolysate preloads, 25 min after the casein preloads and 55 min after the soy protein preloads. The CCK-A receptor antagonist, devazepide (which reverses protein-induced food intake suppression), when given at 0.25 mg/kg, i.p., 60 min before preloads of each of three soy hydrolysates, also blocked suppression of food intake, but the strength and duration of the interaction depended on the preparation. When the two receptor antagonists were both administered with soy or casein preloads, their effects were additive. We conclude that peptides arising from digestion contribute to satiety by independent activation of both opioid and CCK-A receptors.
DOI：
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发表时间：
1998
期刊：
Brain research. Molecular brain research
影响因子：
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作者：
S. Roy;H. C. Liu;H. Loh
通讯作者：
S. Roy;H. C. Liu;H. Loh
胆囊收缩素在大鼠十二指肠输送蛋白胨引起的厌食中的作用。
DOI：
10.1152/ajpregu.1999.276.6.r1701
发表时间：
1999
期刊：
The American journal of physiology.
影响因子：
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作者：
Woltman,T;Reidelberger,R
通讯作者：
Reidelberger,R