ErbB receptors in the biology and pathology of the aerodigestive tract.
ErbB receptors in the biology and pathology of the aerodigestive tract.
复制标题
DOI：
10.1016/j.yexcr.2008.08.009
复制
发表时间：
2009-02-15
影响因子：
3.7
通讯作者：
Grandis JR
中科院分区：
文献类型：
--
作者：
Morgan S;Grandis JR
呼吸消化道中最常见的恶性肿瘤部位包括肺、头颈部和食管。食管腺癌（EA），食管鳞状细胞癌（ESCC）和头颈部鳞状细胞癌（SCCHN）是这篇综述的主要焦点。呼吸消化道癌症的传统治疗包括原发性放化疗（CRT）或手术切除后放疗（或CRT）。治疗的最新进展越来越多地集中在分子靶向策略上，包括西妥昔单抗（一种针对表皮生长因子受体（EGFR）的单克隆抗体）。西妥昔单抗于2006年被FDA批准用于治疗SCCHN，强调了了解这些恶性肿瘤生物学的重要性。EGFR是生长因子受体酪氨酸激酶ErbB家族的成员。ErbB受体激活的主要途径包括Ras/Raf/MAPK、PI 3 K/AKT、PLCγ和STAT，这些途径均导致靶基因的转录，这些靶基因可能有助于呼吸消化道肿瘤的进展。本文就ErbB受体在EA、ESCC和SCCHN中的表达及EGFR在SCCHN中的信号通路作一综述。
The most common sites of malignancies in the aerodigestive tract include the lung, head and neck and the esophagus. Esophageal adenocarcinomas (EA), esophageal squamous cell carcinomas (ESCC), and squamous cell carcinomas of the head and neck (SCCHN) are the primary focus of this review. Traditional treatment for aerodigestive tract cancers includes primary chemoradiotherapy (CRT) or surgical resection followed by radiation (or CRT). Recent developments in treatment have focused increasingly on molecular targeting strategies including cetuximab (a monoclonal antibody against epidermal growth factor receptor (EGFR)). Cetuximab was FDA approved in 2006 for treatment of SCCHN, underscoring the importance of understanding the biology of these malignancies. EGFR is a member of the ErbB family of growth factor receptor tyrosine kinases. The major pathways activated by ErbB receptors include Ras/Raf/MAPK; PI3K/AKT; PLCγ and STATs, all of which lead to the transcription of target genes that may contribute to aerodigestive tumor progression. This review explores the expression of ErbB receptors in EA, ESCC and SCCHN and the signaling pathways of EGFR in SCCHN.
登录
查看更多内容
DOI：
10.1002/hed.20574
发表时间：
2007-07-01
影响因子：
2.9
作者：
Cavalot, Andrea;Martone, Tiziana;Cortesina, Giorgio
通讯作者：
Cortesina, Giorgio
影响因子：
158.5
作者：
Bonner, JA;Harari, PM;Ang, KK
通讯作者：
Ang, KK
影响因子：
11.5
作者：
Erjala, Kaisa;Sundvall, Maria;Elenius, Klaus
通讯作者：
Elenius, Klaus
影响因子：
7.3
作者：
Bei, R;Budillon, A;Muraro, R
通讯作者：
Muraro, R
影响因子：
56.9
作者：
Engelman, Jeffrey A.;Zejnullahu, Kreshnik;Janne, Pasi A.
通讯作者：
Janne, Pasi A.