Anticancer activity of metal complexes: involvement of redox processes.
Anticancer activity of metal complexes: involvement of redox processes.
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DOI：
10.1089/ars.2010.3663
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发表时间：
2011-08-15
影响因子：
6.6
通讯作者：
Heffeter P
中科院分区：
文献类型：
--
作者：
Jungwirth U;Kowol CR;Keppler BK;Hartinger CG;Berger W;Heffeter P
细胞需要细胞内氧化还原平衡的严格调节，因此需要活性氧物质的严格调节以用于适当的氧化还原信号传导和金属（例如，铁和铜）稳态。在包括癌症在内的一些疾病中，这种平衡被打破了。因此，以氧化还原系统为靶点的抗肿瘤药物，如谷胱甘肽和硫氧还蛋白，已成为人们关注的焦点。抗癌金属络合物（铂、金、砷、钌、铑、铜、钒、钴、锰、钆和钼）已显示出与细胞氧化还原稳态强烈相互作用或甚至干扰细胞氧化还原稳态。在这种情况下，特别是"还原活化"的假设以及"硬和软的酸和碱"理论，关于金属离子与细胞配体的配位，代表了理解抗癌金属药物作用的分子模式的重要概念。本综述的目的是突出特定的相互作用的金属为基础的抗癌药物与细胞的氧化还原稳态，并解释这种行为，考虑各自的抗癌金属络合物的化学性质，目前无论是在（预）临床开发或在日常临床常规肿瘤学。
Cells require tight regulation of the intracellular redox balance and consequently of reactive oxygen species for proper redox signaling and maintenance of metal (e.g., of iron and copper) homeostasis. In several diseases, including cancer, this balance is disturbed. Therefore, anticancer drugs targeting the redox systems, for example, glutathione and thioredoxin, have entered focus of interest. Anticancer metal complexes (platinum, gold, arsenic, ruthenium, rhodium, copper, vanadium, cobalt, manganese, gadolinium, and molybdenum) have been shown to strongly interact with or even disturb cellular redox homeostasis. In this context, especially the hypothesis of “activation by reduction” as well as the “hard and soft acids and bases” theory with respect to coordination of metal ions to cellular ligands represent important concepts to understand the molecular modes of action of anticancer metal drugs. The aim of this review is to highlight specific interactions of metal-based anticancer drugs with the cellular redox homeostasis and to explain this behavior by considering chemical properties of the respective anticancer metal complexes currently either in (pre)clinical development or in daily clinical routine in oncology.
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DOI：
10.1084/jem.20100523
发表时间：
2010-04-12
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Abdel-Wahab O;Levine RL
通讯作者：
Levine RL
影响因子：
2.9
作者：
Baldwin, EL;Byl, JAW;Osheroff, N
通讯作者：
Osheroff, N
影响因子：
4.8
作者：
Anestål, K;Arnér, ESJ
通讯作者：
Arnér, ESJ
影响因子：
8.8
作者：
Aird, R E;Cummings, J;Ritchie, A A;Muir, M;Morris, R E;Chen, H;Sadler, P J;Jodrell, D I
通讯作者：
Jodrell, D I
影响因子：
15
作者：
Aguirre, J. Dafhne;Angeles-Boza, Alfredo M.;Dunbar, Kim R.
通讯作者：
Dunbar, Kim R.