Influence of Dietary Metformin on the Growth Performance and Plasma Concentrations of Amino Acids and Advanced Glycation End Products in Two Types of Chickens.
Influence of Dietary Metformin on the Growth Performance and Plasma Concentrations of Amino Acids and Advanced Glycation End Products in Two Types of Chickens.
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DOI：
10.2141/jpsa.0200030
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发表时间：
2021-04-25
期刊：
影响因子：
--
通讯作者：
Tachibana T
中科院分区：
文献类型：
--
作者：
Makino R;Uda M;Shuto S;Kita K;Tachibana T
糖基化是一种诱导葡萄糖与氨基酸和蛋白质结合的非酶反应。糖化氨基酸对蛋白质合成没有作用，这表明糖化降低了氨基酸的利用。二甲双胍（MF）是一种众所周知的抑制糖基化的2型糖尿病治疗药物。这可能是通过抑制糖基化来提高氨基酸的利用，从而改善鸡的生长性能。因此，本试验旨在研究饲粮中添加MF对蛋鸡（试验1）和肉鸡（试验2）生长性能、血浆游离氨基酸和晚期糖基化终产物Nε-（羧甲基）赖氨酸（CML）浓度的影响。从7日龄开始，雏鸡自由饲喂3种添加水平（0、150和300 mg/kg）的MF试验饲粮，为期14 d。每周测定体重和采食量。实验结束时采集血液和胸大肌（m.p ortoralis major）作进一步分析。饲粮中MF对蛋鸡和肉鸡的增重、采食量或饲料效率均无影响。饲粮中添加150 mg/kg的MF可提高蛋鸡和肉鸡胸肌质量。饲粮MF增加了蛋鸡血浆支链氨基酸浓度，降低了CML浓度，但对血浆葡萄糖浓度没有影响。本研究提示，饲粮中添加MF可能通过增加血浆支链氨基酸浓度来增加蛋鸡胸肌质量。
Glycation is a non-enzymatic reaction inducing the bonding of glucose to amino acids and proteins. Glycated amino acids are not useful for protein synthesis, suggesting that glycation reduces the utilization of amino acids. Metformin (MF) is well known as a therapeutic drug for type II diabetes that inhibits glycation. It is possible that treatment with MF raises the utilization of amino acids by the inhibition of glycation, thereby improving the growth performance of chickens. In the present study, therefore, we investigated the influence of dietary MF on the growth performance, and plasma concentrations of free amino acids and Nε-(Carboxymethyl)lysine (CML), which is an advanced glycation end product, in layer (Experiment 1) and broiler (Experiment 2) chickens. From 7 d of age, chicks were allowed free access to one of the experimental diets containing MF at 3 supplementation levels (0, 150, and 300 mg/kg diet) for 14 days. Body weight and feed intake were measured every week. At the end of the experiments, blood and breast muscle (M. pectoralis major) were collected for further analysis. Dietary MF did not affect weight gain, feed intake, or feed efficiency in both layer and broiler chickens. Dietary MF at the level of 150 mg/kg diet increased breast muscle weight in both layer and broiler chickens. Dietary MF increased plasma concentrations of branched chain amino acids and decreased concentrations of CML in layer chickens, although it did not affect plasma concentrations of glucose. The present study suggested that dietary MF might have the potency to increase breast muscle weight of layer chickens with an increment in plasma concentrations of branched-chain amino acids.
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DOI：
10.1016/j.bbrc.2010.01.095
发表时间：
2010-02-26
影响因子：
3.1
作者：
Nagai, Ryoji;Nagai, Mime;Shimasaki, Satoko;Baynes, John W.;Fujiwara, Yukio
通讯作者：
Fujiwara, Yukio
影响因子：
2.6
作者：
Gong L;Goswami S;Giacomini KM;Altman RB;Klein TE
通讯作者：
Klein TE
影响因子：
8.2
作者：
Rena, Graham;Pearson, Ewan R.;Sakamoto, Kei
通讯作者：
Sakamoto, Kei
影响因子：
4.8
作者：
Onorato, JM;Jenkins, AJ;Baynes, JW
通讯作者：
Baynes, JW
影响因子：
7.7
作者：
Babaei-Jadidi, R;Karachalias, N;Thornalley, PJ
通讯作者：
Thornalley, PJ