Metal ion sensors based on DNAzymes and related DNA molecules.
Metal ion sensors based on DNAzymes and related DNA molecules.
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DOI:
10.1146/annurev.anchem.111808.073617
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发表时间:
2011
期刊:
影响因子:
--
通讯作者:
Lu Y
中科院分区:
文献类型:
--
作者:
Zhang XB;Kong RM;Lu Y
Metal ion sensors are an important yet challenging field in analytical chemistry. Despite much effort, only a limited number of metal ion sensors are available for practical use because sensor design is often a trial-and-error-dependent process. DNAzyme-based sensors, in contrast, can be developed through a systematic selection that is generalizable for a wide range of metal ions. Here, we summarize recent progress in the design of DNAzyme-based fluorescent, colorimetric, and electrochemical sensors for metal ions, such as Pb2+, Cu2+, Hg2+, and UO22+ In addition, we also describe metal ion sensors based on related DNA molecules, including T-T or C-C mismatches and G-quadruplexes.
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