Physiologic role of the complement system in host defense, disease, and malnutrition.
Physiologic role of the complement system in host defense, disease, and malnutrition.
复制标题
补体系统在宿主防御、疾病和营养不良中的生理作用。
DOI：
10.1016/s0899-9007(97)00473-5
复制
发表时间：
1998
期刊：
影响因子：
4.4
通讯作者：
Kusuya Nishioka
中科院分区：
文献类型：
--
作者：
M. Sakamoto;Y. Fujisawa;Kusuya Nishioka
补体系统作为融合早期先天免疫和后期获得性免疫的系统的作用已经确立。C3是补体系统的关键蛋白。它在四种途径中被激活：（1）替代途径，（2）甘露聚糖结合蛋白途径，（3）C-反应蛋白途径，和（4）先天免疫中的天然IgM途径。它也在（1）经典途径中被激活，即，通过抗原-抗体复合物，和（2）通过获得性免疫中受损的宿主细胞。C3的活化导致多种免疫反应，如免疫粘附、吞噬作用、抗体应答、细胞溶解、炎症和杀死病原微生物。本文综述了补体系统在各种疾病中的病理学表现。注意力集中在营养不良状态下的低补体血症。在人类和实验动物中，观察到补体水平降低，特别是C3水平降低，与宿主对感染的防御能力降低有关。低补体血症改善营养康复后，伴随着临床症状的改善和宿主抵抗力的恢复。在营养不良或营养良好的大鼠中，C3水平的提高导致对细菌感染的抵抗力增强。在这些实验和临床观察的基础上，我们获得了预防或治疗营养不良状态下宿主防御系统受损的线索。
The role of the complement system as a system merging early-phase innate immunity with later-phase acquired immunity has been established. C3 is a key protein of the complement system. It is activated in four pathways: (1) the alternative pathway, (2) the mannan binding protein pathway, (3) the C-reactive protein pathway, and (4) the natural IgM pathway in innate immunity. It is also activated in (1) a classic pathway, i.e., through an antigen-antibody complex, and (2) by injured host cells in acquired immunity. Activation of C3 results in a variety of immunologic reactions such as immune adherence, phagocytosis, antibody response, cytolysis, inflammation, and killing of pathogenic microorganisms. Pathologic pictures of the complement system in various diseases were reviewed. Attention was focused on hypocomplementemia in the malnourished state. In humans and in experimental animals, reduced complement levels, especially of C3, were observed in relation to lowered host defense against infection. Hypocomplementemia improved after nutritional rehabilitation with a concomitant improvement of the clinical picture and recovery of host resistance. Enhancement of C3 levels in malnourished or well-nourished rats resulted in heightened resistance against bacterial infections. On the basis of these experimental and clinical observations, we obtained clues to prevent or treat a compromised host defense system in malnourished states.
登录
查看更多内容
影响因子：
56.9
作者：
Fearon, DT;Locksley, RM
通讯作者：
Locksley, RM
癌胎抗原 IgM 抗体升高的黑色素瘤患者的生存期延长。
DOI：
--
发表时间：
1981
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Jones,PC;Sze,LL;Liu,PY;Morton,DL;Irie,RF
通讯作者：
Irie,RF
影响因子：
1.6
作者：
LLOYD, W;SCHUR, PH
通讯作者：
SCHUR, PH
CR2 是补体激活剂，也是 Raji 细胞激活旁路途径期间 C3 的共价结合位点。
DOI：
--
发表时间：
1988
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Mold,C;Nemerow,GR;Bradt,BM;Cooper,NR
通讯作者：
Cooper,NR
影响因子：
10.5
作者：
Schur,PH
通讯作者：
Schur,PH