Myocardial protection with and without leukocyte depletion: a comparative study on the oxidative stress.
Myocardial protection with and without leukocyte depletion: a comparative study on the oxidative stress.
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有和没有白细胞耗竭的心肌保护：氧化应激的比较研究。
DOI：
10.1016/s1010-7940(05)80129-0
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
V. Agape
中科院分区：
文献类型：
--
作者：
M. Pala;G. Paolini;R. Paroni;E. De Veechi;C. Gallorini;P. Stefàno;G. Di Credico;M. Zuccari;L. Galli;V. Agape
我们验证了这样的假设，即用去白细胞的血液进行控制再灌流可以通过减少心肌血管重建术患者的氧化应激来改善心肌保护。34例顺行/逆行血停搏液患者分为A组11例射血分数(EF)<35%，B组11例EF<35%不去白细胞，C组6例EF>45%为A组，D组6例EF>45%不去白细胞。为评估氧化应激，我们测定了冠状静脉窦血浆中总、总氧化(GSSX)和还原型谷胱甘肽(GSH)的含量，分别在阻断前(T0)、开放后0(T1)、15(T2)和30(T3)分钟。在A组和B组中，谷胱甘肽的氧化还原状态(GSH/GSSX)在T1比T0有明显的转变。B组谷胱甘肽氧化还原比率维持在较低水平，而A组在T2时恢复到基础值，与B组在T2和T3时有显着性差异。C组与D组之间无明显差异。结论：去白细胞再灌注对左心功能不全患者有较好的心肌保护作用，而对EF正常的患者则无此作用。
We tested the hypothesis that controlled reperfusion with leukocyte-depleted blood could improve myocardial protection by reducing the oxidative stress in patients undergoing myocardial revascularization. Thirty-four patients receiving antegrade/retrograde blood cardioplegia were divided into: group A: 11 patients with ejection fractions (EF) less than 35%, treated with leukocyte-depleted controlled blood reperfusion, group B: 11 patients with EF less than 35% in whom no leukocyte depletion was performed, group C: 6 patients with EF more than 45% treated as group A and group D: 6 patients with EF more than 45% without leukocyte depletion. To asses the oxidative stress, we evaluated total, total oxidized (GSSX), and reduced glutathione (GSH) in coronary sinus plasma, immediately before cross-clamping the aorta (T0), and at 0 (T1), 15 (T2) and 30 (T3) min after unclamping it. In groups A and B a significant shift towards oxidation of redox status of glutathione (GSH/GSSX) at T1 vs T0 was observed. Glutathione redox ratio remained low in group B while in group A it returned to the basal value at T2 with a significant difference from group B at T2 and T3. No differences were observed between groups C and D. In conclusion, our data show that leukocyte-depleted reperfusion can afford a better myocardial protection in patients with left ventricular dysfunction, while it seems unnecessary in patients with normal EF.
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影响因子：
37.8
作者：
LITT, MR;JEREMY, RW;BECKER, LC
通讯作者：
BECKER, LC
慢性心电图 Q 波梗塞患者的区域灌注、葡萄糖代谢和室壁运动：通过正电子发射断层扫描证明某些梗塞区域存活组织持续存在的证据。
影响因子：
37.8
作者：
Brunken,R;Tillisch,J;Schwaiger,M;Child,JS;Marshall,R;Mandelkern,M;Phelps,ME;Schelbert,HR
通讯作者：
Schelbert,HR
DOI：
--
发表时间：
1991
期刊：
The Journal of thoracic and cardiovascular surgery
影响因子：
--
作者：
Julia,PL;Buckberg,GD;Acar,C;Partington,MT;Sherman,MP
通讯作者：
Sherman,MP
通过白细胞和血小板消耗减轻心肌顿抑。
影响因子：
37.8
作者：
Westlin,W;Mullane,KM
通讯作者：
Mullane,KM
心肌再灌注损伤的机制和治疗。
影响因子：
37.8
作者：
Forman,MB;Virmani,R;Puett,DW
通讯作者：
Puett,DW