Widespread hyperphosphorylated tau in the working memory circuit early after cortical impact injury of brain (Original study)
Widespread hyperphosphorylated tau in the working memory circuit early after cortical impact injury of brain (Original study)
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大脑皮质撞击损伤后早期工作记忆回路中广泛存在过度磷酸化的 tau 蛋白（原始研究）
DOI：
10.1016/j.bbr.2017.02.002
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发表时间：
2017-04
影响因子：
2.7
通讯作者：
Zhou Yuan-Guo
中科院分区：
文献类型：
--
作者：
Zhao Zi-Ai;Ning Ya-Lei;Li Ping;Yang Nan;Peng Yan;Xiong Ren-Ping;Zhao Yan;Liu Dong;Zeng Xu-Jia;Chen Jiang-Fan;Zhou Yuan-Guo
创伤性脑损伤（traumatic brain injury，TBI）后会出现一系列神经和精神症状，其中认知功能障碍是最突出的后遗症之一。鉴于tau蛋白过度磷酸化是阿尔茨海默病患者认知障碍的重要原因，我们目前的研究检测了过度磷酸化tau蛋白（p-tau）的存在，主要是在Ser404，在多个脑区，包括同侧顶叶皮质，对侧海马和前额皮质，在小鼠TBI模型损伤后立即，这些变化持续至少4周。所有这些大脑区域都在工作记忆中发挥着重要作用。过度磷酸化的tau蛋白主要定位于神经元，并伴有轴突损伤和树突棘变性。我们的研究表明，p-tau在TBI后逐渐并选择性地从受损皮层扩散到其他脑区，并且所有受影响的区域都是工作记忆回路的一部分。这些发现为p-tau在TBI后早期认知障碍中的作用提供了实验支持。
A series of neurological and psychiatric symptoms occur after traumatic brain injury (TBI), with cognitive dysfunction being one of the most prominent sequela. Given that tau hyperphosphorylation is an important cause of cognitive impairment in patients of Alzheimer's disease, our present study detected the presence of hyperphosphorylated tau (p-tau), mainly at Ser404, in multiple brain regions, including the ipsilateral parietal cortex, contralateral hippocampus and prefrontal cortex, immediately after the injury in a mouse TBI model; these changes lasted for at least 4 w. All of these brain regions play important roles in working memory. Hyperphosphorylated tau protein was primarily located in neurons and was accompanied by axonal injury and dendritic spine degeneration. Our study demonstrated that p-tau spreads gradually and selectively from the injured cortex to other brain regions after TBI and that all of the affected regions are part of the working memory circuit. These findings provide experimental support for the role of p-tau in cognitive impairment in the early phase after TBI.
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影响因子：
3
作者：
Jin J;Maren S
通讯作者：
Maren S
影响因子：
17.1
作者：
Goldstein LE;Fisher AM;Tagge CA;Zhang XL;Velisek L;Sullivan JA;Upreti C;Kracht JM;Ericsson M;Wojnarowicz MW;Goletiani CJ;Maglakelidze GM;Casey N;Moncaster JA;Minaeva O;Moir RD;Nowinski CJ;Stern RA;Cantu RC;Geiling J;Blusztajn JK;Wolozin BL;Ikezu T;Stein TD;Budson AE;Kowall NW;Chargin D;Sharon A;Saman S;Hall GF;Moss WC;Cleveland RO;Tanzi RE;Stanton PK;McKee AC
通讯作者：
McKee AC
DOI：
10.1073/pnas.0908563106
发表时间：
2009-10-20
影响因子：
11.1
作者：
Hains, Avis Brennan;Vu, Mai Anh T.;Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.
影响因子：
3.4
作者：
Liu, Fei;Li, Bin;Gong, Cheng-Xin
通讯作者：
Gong, Cheng-Xin
影响因子：
6
作者：
Callahan, MJ;Lipinski, WJ;Walker, LC
通讯作者：
Walker, LC