Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample.
Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample.
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DOI：
10.1186/1475-2840-7-5
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发表时间：
2008-03-13
影响因子：
9.3
通讯作者：
Hegele RA
中科院分区：
文献类型：
--
作者：
Al-Attar SA;Pollex RL;Ban MR;Young TK;Bjerregaard P;Anand SS;Yusuf S;Zinman B;Harris SB;Hanley AJ;Connelly PW;Huff MW;Hegele RA
先前已发现FTO基因中的rs9939609 T>A单核苷酸多态性（SNP）与欧洲高加索人样本中的肥胖相关。本研究的目的是检验这种关联是否延伸至代谢综合征（MetS）以及是否适用于非高加索人样本。
对来自四个不同非高加索人地理血统的2121名受试者的FTO rs9939609 SNP进行了基因分型。根据国际糖尿病联盟（IDF）和美国国家胆固醇教育计划成人治疗小组（NCEP ATP）III的定义，对受试者是否患有MetS进行分类。
携带≥1份rs9939609 A等位基因的个体患IDF定义的MetS（35.8%）的可能性显著高于非携带者（31.2%），对应的携带者优势比（OR）为1.23（95%置信区间[CI]为1.01 - 1.50），对于NCEP ATP III定义的MetS也有类似趋势。亚组分析表明，这种关联在男性中尤为强烈。这种关联与符合腰围标准的rs9939609 A等位基因携带者比例较高有关；与野生型纯合子相比，符合高密度脂蛋白胆固醇标准的比例也更高。
因此，在这个多种族样本中，FTO rs9939609 SNP与MetS风险增加相关，证实了这种关联延伸至非高加索人群样本。
The rs9939609 T>A single-nucleotide polymorphism (SNP) in the FTO gene has previously been found to be associated with obesity in European Caucasian samples. The objective of this study is to examine whether this association extends to metabolic syndrome (MetS) and applies in non-Caucasian samples. The FTO rs9939609 SNP was genotyped in 2121 subjects from four different non-Caucasian geographical ancestries. Subjects were classified for the presence or absence of MetS according to the International Diabetes Federation (IDF) and National Cholesterol Education Program Adult Treatment Panel (NCEP ATP) III definitions. Carriers of ≥ 1 copy of the rs9939609 A allele were significantly more likely to have IDF-defined MetS (35.8%) than non-carriers (31.2%), corresponding to a carrier odds ratio (OR) of 1.23 (95% confidence interval [CI] 1.01 to 1.50), with a similar trend for the NCEP ATP III-defined MetS. Subgroup analysis showed that the association was particularly strong in men. The association was related to a higher proportion of rs9939609 A allele carriers meeting the waist circumference criterion; a higher proportion also met the HDL cholesterol criterion compared with wild-type homozygotes. Thus, the FTO rs9939609 SNP was associated with an increased risk for MetS in this multi-ethnic sample, confirming that the association extends to non-Caucasian population samples.
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DOI：
10.1126/science.1151710
发表时间：
2007-11-30
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gerken T;Girard CA;Tung YC;Webby CJ;Saudek V;Hewitson KS;Yeo GS;McDonough MA;Cunliffe S;McNeill LA;Galvanovskis J;Rorsman P;Robins P;Prieur X;Coll AP;Ma M;Jovanovic Z;Farooqi IS;Sedgwick B;Barroso I;Lindahl T;Ponting CP;Ashcroft FM;O'Rahilly S;Schofield CJ
通讯作者：
Schofield CJ
影响因子：
56.9
作者：
Frayling, Timothy M.;Timpson, Nicholas J.;McCarthy, Mark I.
通讯作者：
McCarthy, Mark I.
DOI：
10.1111/j.1559-4564.2007.05905.x
发表时间：
2007-01-01
期刊：
Journal of the cardiometabolic syndrome
影响因子：
--
作者：
Yuan, George;Hegele, Robert A
通讯作者：
Hegele, Robert A
影响因子：
120.7
作者：
Cleeman, JI;Grundy, SM;Murray, EZ
通讯作者：
Murray, EZ
影响因子：
56.9
作者：
Scott, Laura J.;Mohlke, Karen L.;Boehnke, Michael
通讯作者：
Boehnke, Michael