Schwann Cells Induce Phenotypic Changes in Oral Cancer Cells.
Schwann Cells Induce Phenotypic Changes in Oral Cancer Cells.
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DOI：
10.1002/adbi.202200187
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发表时间：
2022-09
期刊：
影响因子：
3.7
通讯作者：
Ye, Yi
中科院分区：
文献类型：
--
作者：
Santi, Maria Daniela;Zhang, Morgan;Salvo, Elizabeth;Asam, Kesava;Viet, Chi T.;Xie, Tongxin;Amit, Moran;Aouizerat, Bradley;Ye, Yi
关键词：
头颈癌（HNC）是世界上第七大常见癌症，其中大多数是口腔鳞状细胞癌。尽管癌症诊断和治疗取得了进展，但HNC患者的生存率仍然停滞不前。癌症-神经相互作用已被认为是癌症进展的重要驱动因素。雪旺细胞是一种外周神经胶质细胞，在许多癌症中参与促进癌细胞生长、迁移、分散和侵入神经。在这里，我们证明了许旺细胞的存在使口腔癌细胞更具侵略性，通过促进其增殖，细胞外基质分解，改变细胞代谢。此外，与许旺细胞共培养后，口腔癌细胞变得更大、更圆、有更多的突起和细胞核。暴露于许旺细胞后口腔癌细胞中的RNA测序分析显示了参与癌症和细胞代谢标志的基因的相应变化;富集的KEGG途径是剪接体、RNA转运、细胞周期、轴突导向、调节干细胞多能性的信号传导途径、cAMP信号传导、WNT信号传导、癌症中的蛋白聚糖和PI 3 K-Akt信号传导。综上所述，这些结果表明许旺细胞在促进口腔癌进展方面具有重要作用，突出了它们作为治疗口腔癌进展的靶点的潜力。许旺细胞的存在诱导口腔癌细胞的形态、行为和分子变化，可能将口腔癌细胞转化为更具侵袭性的表型。
Head and neck cancer (HNC) is the seventh most common cancer worldwide, with the majority being oral squamous cell carcinoma. Despite advances in cancer diagnosis and treatment, the survival rate of patients with HNC remains stagnant. The cancer-nerve interaction has been recognized as an important driver of cancer progression. Schwann cells, a type of peripheral glia, have been implicated in promoting cancer cell growth, migration, dispersion, and invasion into the nerve in many cancers. Here, we demonstrate that the presence of Schwann cells makes oral cancer cells more aggressive by promoting its proliferation, extracellular matrix breakdown, and altering cell metabolism. Furthermore, oral cancer cells became larger, more circular, with more projections and nuclei following co-culturing with Schwann cells. RNA-sequencing analysis in oral cancer cells following exposure to Schwann cells shows corresponding changes in genes involved in the hallmarks of cancer and cell metabolism; the enriched KEGG pathways were spliceosome, RNA transport, cell cycle, axon guidance, signaling pathways regulating pluripotency of stem cells, cAMP signaling, WNT signaling, proteoglycans in cancer and PI3K-Akt signaling. Taken together, these results suggest a significant role for Schwann cells in facilitating oral cancer progression, highlighting their potential as a target to treat oral cancer progression. The presence of Schwann cells induces morphological, behavioral, and molecular changes in oral cancer cells, possibly converting oral cancer cells into a more aggressive phenotype.
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影响因子：
9
作者：
Chang CW;Chen YS;Tsay YG;Han CL;Chen YJ;Yang CC;Hung KF;Lin CH;Huang TY;Kao SY;Lee TC;Lo JF
通讯作者：
Lo JF
影响因子：
6.4
作者：
Goertzen C;Eymael D;Magalhaes M
通讯作者：
Magalhaes M
影响因子：
8.8
作者：
Baffy, G.;Derdak, Z.;Robson, S. C.
通讯作者：
Robson, S. C.
DOI：
10.1002/hed.26746
发表时间：
2021-09
期刊：
Head & neck
影响因子：
--
作者：
Boeve K;Mastik MF;Slagter-Menkema L;van Dijk BAC;Roodenburg JLN;van der Laan BFAM;Witjes MJH;van der Vegt B;Schuuring E
通讯作者：
Schuuring E
影响因子：
3.7
作者：
Gemenetzidis E;Bose A;Riaz AM;Chaplin T;Young BD;Ali M;Sugden D;Thurlow JK;Cheong SC;Teo SH;Wan H;Waseem A;Parkinson EK;Fortune F;Teh MT
通讯作者：
Teh MT