Regulation of phosphoinositide metabolism in Apicomplexan parasites.
Regulation of phosphoinositide metabolism in Apicomplexan parasites.
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DOI：
10.3389/fcell.2023.1163574
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发表时间：
2023
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
磷酸肌苷是生物学上必不可少的一类磷脂，有助于细胞器膜的识别，调节膜运输途径，是真核生物细胞膜细胞质表面主要信号转导途径的中心成分。顶复体（如刚地弓形虫和疟原虫）是专性细胞内寄生虫，是动物和人类疾病的重要病原体。近年来关于顶复合体寄生物分子和细胞生物学的研究进展揭示了磷酸肌苷信号在寄生物发病的关键方面的重要作用。这些包括侵袭宿主细胞，细胞内存活和复制，从宿主细胞中退出，以及细胞外运动。由于顶复合体已经适应了基本信号通路的组织，以适应其复杂的寄生生活方式，这些生物为研究磷酸肌苷信号的进化、保护和再利用提供了实验上可处理的系统。本文综述了顶复体寄生虫疟原虫和弓形虫体内磷酸肌苷的时空调控机制。我们进一步讨论了顶复合体磷酸化肌肽信号在其他真核生物中如何调控的异同。
Phosphoinositides are a biologically essential class of phospholipids that contribute to organelle membrane identity, modulate membrane trafficking pathways, and are central components of major signal transduction pathways that operate on the cytosolic face of intracellular membranes in eukaryotes. Apicomplexans (such as Toxoplasma gondii and Plasmodium spp.) are obligate intracellular parasites that are important causative agents of disease in animals and humans. Recent advances in molecular and cell biology of Apicomplexan parasites reveal important roles for phosphoinositide signaling in key aspects of parasitosis. These include invasion of host cells, intracellular survival and replication, egress from host cells, and extracellular motility. As Apicomplexans have adapted to the organization of essential signaling pathways to accommodate their complex parasitic lifestyle, these organisms offer experimentally tractable systems for studying the evolution, conservation, and repurposing of phosphoinositide signaling. In this review, we describe the regulatory mechanisms that control the spatial and temporal regulation of phosphoinositides in the Apicomplexan parasites Plasmodium and T. gondii. We further discuss the similarities and differences presented by Apicomplexan phosphoinositide signaling relative to how these pathways are regulated in other eukaryotic organisms.
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影响因子：
4.8
作者：
Brown, Kevin M.;Lourido, Sebastian;Sibley, L. David
通讯作者：
Sibley, L. David
DOI：
10.1083/jcb.108.4.1271
发表时间：
1989-04
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bankaitis VA;Malehorn DE;Emr SD;Greene R
通讯作者：
Greene R
影响因子：
5.6
作者：
Khan D;Nile AH;Tripathi A;Bankaitis VA
通讯作者：
Bankaitis VA
影响因子：
6.7
作者：
Bansal P;Antil N;Kumar M;Yamaryo-Botté Y;Rawat RS;Pinto S;Datta KK;Katris NJ;Botté CY;Prasad TSK;Sharma P
通讯作者：
Sharma P
影响因子：
4.5
作者：
Filipuzzi I;Cotesta S;Perruccio F;Knapp B;Fu Y;Studer C;Pries V;Riedl R;Helliwell SB;Petrovic KT;Movva NR;Sanglard D;Tao J;Hoepfner D
通讯作者：
Hoepfner D