Intratumor Heterogeneity in Hepatocellular Carcinoma: Challenges and Opportunities.
Intratumor Heterogeneity in Hepatocellular Carcinoma: Challenges and Opportunities.
复制标题
DOI：
10.3390/cancers13215524
复制
发表时间：
2021-11-03
期刊：
影响因子：
5.2
通讯作者：
Evason KJ
中科院分区：
文献类型：
--
作者：
Kalasekar SM;VanSant-Webb CH;Evason KJ
肝细胞癌（HCC）是一种致命的肝癌，患者预后和生存率都很差。与许多其他癌症不同，HCC尚未看到个体化治疗的益处。HCC难以治疗的部分原因是由于每个肿瘤的不同区域之间的差异，也称为肿瘤内异质性（ITH）。在这篇综述中，我们总结了什么是已知的原发性肝癌，描述了它如何影响肿瘤的行为和治疗策略，并讨论了未来的研究方向，原发性肝癌和原发性肝癌。肝细胞癌（HCC）是癌症相关死亡的主要原因，但它仍然很难治疗。肿瘤内遗传和表型异质性是乳腺癌、皮肤癌、肺癌、前列腺癌和脑瘤的固有特性，肿瘤内异质性（ITH）有助于确定这些癌症的预后和治疗反应。一些最近的研究估计，ITH是固有的HCC和属性的HCC的临床难治性，这种异质性。在这篇综述中，我们研究了HCC中基因组、表型和肿瘤微环境ITH的证据，重点关注HCC的两个顶级分子驱动因子：β-连环蛋白（CTNNB 1）和端粒酶逆转录酶（TERT）。我们讨论了ITH对HCC诊断、预后和治疗的影响，同时强调了知识上的差距和未来可能的方向。
Hepatocellular carcinoma (HCC) is a deadly form of liver cancer that has poor patient outcomes and survival. Unlike many other cancers, HCC has not seen the benefit of individualized treatment. Part of the reason HCC is hard to treat is due to differences among distinct regions of each tumor, also known as intratumor heterogeneity (ITH). In this review, we summarize what is known about ITH in HCC, describe how it influences tumor behavior and treatment strategies, and discuss future research directions for ITH and HCC. Hepatocellular carcinoma (HCC) represents a leading cause of cancer-related death, but it remains difficult to treat. Intratumor genetic and phenotypic heterogeneity are inherent properties of breast, skin, lung, prostate, and brain tumors, and intratumor heterogeneity (ITH) helps define prognosis and therapeutic response in these cancers. Several recent studies estimate that ITH is inherent to HCC and attribute the clinical intractability of HCC to this heterogeneity. In this review, we examine the evidence for genomic, phenotypic, and tumor microenvironment ITH in HCC, with a focus on two of the top molecular drivers of HCC: β-catenin (CTNNB1) and Telomerase reverse transcriptase (TERT). We discuss the influence of ITH on HCC diagnosis, prognosis, and therapy, while highlighting the gaps in knowledge and possible future directions.
登录
查看更多内容
使用微滴式数字 PCR 检测肝细胞癌患者的循环肿瘤 DNA 是可行的，并反映了瘤内异质性
影响因子：
3.9
作者：
Huang A;Zhang X;Zhou SL;Cao Y;Huang XW;Fan J;Yang XR;Zhou J
通讯作者：
Zhou J
影响因子：
7.3
作者：
Bashashati, Ali;Ha, Gavin;Tone, Alicia;Ding, Jiarui;Prentice, Leah M.;Roth, Andrew;Rosner, Jamie;Shumansky, Karey;Kalloger, Steve;Senz, Janine;Yang, Winnie;McConechy, Melissa;Melnyk, Nataliya;Anglesio, Michael;Luk, Margaret T. Y.;Tse, Kane;Zeng, Thomas;Moore, Richard;Zhao, Yongjun;Marra, Marco A.;Gilks, Blake;Yip, Stephen;Huntsman, David G.;McAlpine, Jessica N.;Shah, Sohrab P.
通讯作者：
Shah, Sohrab P.
影响因子：
3.1
作者：
Hayano, Koichi;Yoshida, Hiroyuki;Sahani, Dushyant V.
通讯作者：
Sahani, Dushyant V.
影响因子：
2.8
作者：
Brabletz, T;Jung, A;Kirchner, T
通讯作者：
Kirchner, T
影响因子：
25.7
作者：
Calderaro, Julien;Petitprez, Florent;Sautes-Fridman, Catherine
通讯作者：
Sautes-Fridman, Catherine