The role of mitochondria in health and disease.
The role of mitochondria in health and disease.
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DOI：
10.1016/j.coph.2009.09.002
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发表时间：
2009-12
影响因子：
4
通讯作者：
Ravussin, Eric
中科院分区：
文献类型：
--
作者：
Johannsen, Darcy L.;Ravussin, Eric
线粒体在许多组织的能量代谢中起着关键作用，包括骨骼肌和肝脏。线粒体的先天疾病，如DNA缺失，会导致新陈代谢的严重中断，并可能导致严重的损伤或死亡。然而，这种疾病的发生极其罕见，不能解释大多数代谢性疾病。近年来，以胰岛素抵抗为特征的慢性代谢性疾病如肥胖症、2型糖尿病和衰老的病理改变与骨骼肌线粒体功能障碍密切相关。舒尔曼和他的同事的工作证实了这一假设，表明随着年龄的增长，线粒体氧化能力的降低是肌肉内脂肪积累导致胰岛素抵抗的基础。然而，Nair和他的同事最近的研究表明，接触高卡路里饮食导致肥胖的人的线粒体活性实际上可能更高，这表明肌肉内脂肪和相关脂肪酸代谢物的积累可能直接导致胰岛素抵抗的发展，而不是线粒体的功能。这些不一致的发现促进了对线粒体功能的持续研究，以确定功能受损是代谢紊乱的原因还是结果。
Mitochondria play a key role in energy metabolism in many tissues, including skeletal muscle and liver. Inherent disorders of mitochondria such as DNA deletions cause major disruption of metabolism and can result in severe impairment or death. However, the occurrence of such disorders is extremely rare and cannot account for the majority of metabolic disease. Recently, mitochondrial dysfunction of a more subtle nature in skeletal muscle has been implicated in the pathology of chronic metabolic disease characterized by insulin resistance such as obesity, type 2 diabetes mellitus, and aging. This hypothesis has been substantiated by work from Shulman and colleagues, showing that reduced mitochondrial oxidative capacity underlies the accumulation of intramuscular fat causing insulin resistance with aging. However, recent work by Nair and coworkers has demonstrated that mitochondrial activity may actually be higher in persons exposed to high-calorie diet leading to obesity, suggesting that the accumulation of intramuscular fat and associated fatty acid metabolites may be directly responsible for the development of insulin resistance, independent of mitochondrial function. These inconsistent findings have promoted ongoing investigation into mitochondrial function to determine whether impaired function is a cause or consequence of metabolic disorders.
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影响因子：
158.5
作者：
BOUCHARD, C;TREMBLAY, A;FOURNIER, G
通讯作者：
FOURNIER, G
胰岛素2型糖尿病父母的胰岛素耐药后代的胰岛素刺激的ATP合成和磷酸盐转运减少。
影响因子：
15.8
作者：
Petersen, KF;Dufour, S;Shulman, GI
通讯作者：
Shulman, GI
DOI：
10.1093/gerona/61.6.534
发表时间：
2006-06-01
影响因子：
5.1
作者：
Menshikova, Elizabeth V.;Ritov, Vladimir B.;Goodpaster, Bret H.
通讯作者：
Goodpaster, Bret H.
DOI：
10.1073/pnas.1032913100
发表时间：
2003-07-08
影响因子：
11.1
作者：
Patti, ME;Butte, AJ;Mandarino, LJ
通讯作者：
Mandarino, LJ
影响因子：
15.9
作者：
Anderson, Ethan J.;Lustig, Mary E.;Neufer, P. Darrell
通讯作者：
Neufer, P. Darrell