Experimental study of tetrodotoxin, a long-acting topical anesthetic.
Experimental study of tetrodotoxin, a long-acting topical anesthetic.
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长效局部麻醉剂河豚毒素的实验研究。
DOI：
10.1016/s0002-9394(99)80188-3
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发表时间：
1998
影响因子：
4.2
通讯作者：
Jones,MR
中科院分区：
文献类型：
--
作者：
Schwartz,DM;Fields,HL;Duncan,KG;Duncan,JL;Jones,MR
PURPOSETo determine the effectiveness and toxicity of tetrodotoxin for use as a long-acting topical anesthetic.METHODSFour groups of six rabbits each received a 40-μl aliquot of either tetrodotoxin in one of three concentrations (10 mM, 1 mM, or 0.1 mM) or proparacaine 0.5% into the inferior conjunctival cul-de-sac of one eye, with the fellow eye of each rabbit receiving 40 μl of a 60-mM, pH 4.3 sodium citrate vehicle as a control. Corneal sensation was tested for up to 8 hours after administration of drugs, and response was noted by no blink, partial blink without full eyelid closure, and full blink. Slit-lamp examination at 12 and 24 hours after administration and pachymetry before and 24 hours after administration were performed to detect corneal toxicity.RESULTSRabbits receiving all three concentrations of tetrodotoxin did not demonstrate any ocular irritation, corneal thickening, or signs of systemic toxicity. At a dose of 10 mM, tetrodotoxin produced an anesthetic effect lasting up to 8 hours. At 1 mM, tetrodotoxin was an effective but shorter-acting anesthetic. At 0.1 mM, tetrodotoxin had no significant anesthetic effect. Proparacaine-treated rabbits initially were anesthetic, but this effect was largely gone by 1 hour and completely gone by 3 hours.CONCLUSIONSTetrodotoxin is a long-acting topical anesthetic in the rabbit cornea. Although additional toxicity studies are required, tetrodotoxin may provide an effective, long-lasting topical anesthetic for use in pain control after corneal procedures such as photorefractive keratectomy.
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影响因子：
4.2
作者：
Maurice,DM;Singh,T
通讯作者：
Singh,T
河豚毒素：从毒药到强大的工具
影响因子：
1
作者：
J. Blankenship
通讯作者：
J. Blankenship
控制屈光性角膜切除术后的疼痛。
影响因子：
2.4
作者：
S. Verma;J. Marshall
通讯作者：
J. Marshall
对塔里查毒素（一种强效神经毒素）的药理学研究。
影响因子：
3.5
作者：
C. Y. Kao;F. A. Fuhrman
通讯作者：
F. A. Fuhrman
准分子激光屈光性角膜切除术后疼痛的治疗：局麻药滴剂、局部双氯芬酸和绷带软接触的叠加作用。
DOI：
--
发表时间：
1996
期刊：
影响因子：
--
作者：
Cherry Pm
通讯作者：
Cherry Pm