Neuroprotective effect and potential of cellular prion protein and its cleavage products for treatment of neurodegenerative disorders part I. a literature review.
Neuroprotective effect and potential of cellular prion protein and its cleavage products for treatment of neurodegenerative disorders part I. a literature review.
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细胞朊蛋白及其裂解产物对神经退行性疾病的神经保护作用和治疗潜力第一部分。文献综述。
DOI：
10.1080/14737175.2021.1965881
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发表时间：
2021-09
影响因子：
4.3
通讯作者：
Kong Q
中科院分区：
文献类型：
--
作者：
Dexter E;Kong Q
细胞内的PrPC蛋白因其在Prion疾病、其他几种神经退行性疾病(如阿尔茨海默病)和多种癌症中的致病作用而广为人知，但PrPC及其切割产物的有益方面受到的关注要少得多。本文系统地综述了PrPC及其衍生物(尤其是PrP、N-末端N1肽和脱落PrP)的负性和保护性方面的文献。作者将剖析目前关于N1和Shap PrP的发现，包括它们神经保护作用的证据，PrPC裂解的类别，以及涉及的许多裂解酶。作者还将讨论富含PrPC的外切体的保护作用和治疗潜力。引用的文章是从PubMed对最新文献的广泛搜索中获得的，包括同行评议的原始文章和综述文章。PrP及其N-末端片段具有很强的神经保护活性，可用于PrP、阿尔茨海默病和其他几种神经退行性疾病的治疗和预防。为这些神经退行性疾病开发基于PrP的治疗和预防的策略将在一篇配套文章(第二部分)中讨论。
The cellular prion protein (PrPC) is well known for its pathogenic roles in prion diseases, several other neurodegenerative diseases (such as Alzheimer’s disease), and multiple types of cancer, but the beneficial aspects of PrPC and its cleavage products received much less attention. Here the authors will systematically review the literatures on the negative as well as protective aspects of PrPC and its derivatives (especially PrP N-terminal N1 peptide and shed PrP). The authors will dissect the current findings on N1 and shed PrP, including evidence for their neuroprotective effects, the categories of PrPC cleavage, and numerous cleavage enzymes involved. The authors will also discuss the protective effects and therapeutic potentials of PrPC-rich exosomes. The cited articles were obtained from extensive PubMed searches of recent literature, including peer-reviewed original articles and review articles. PrP and its N-terminal fragments have strong neuroprotective activities that should be explored for therapeutics and prophylactics development against prion disease, Alzheimer’s disease and a few other neurodegenerative diseases. The strategies to develop PrP-based therapeutics and prophylactics for these neurodegenerative diseases will be discussed in a companion article (Part II).
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影响因子：
4.6
作者：
Aulić S;Masperone L;Narkiewicz J;Isopi E;Bistaffa E;Ambrosetti E;Pastore B;De Cecco E;Scaini D;Zago P;Moda F;Tagliavini F;Legname G
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Legname G
影响因子：
11.1
作者：
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通讯作者：
Aguzzi, Adriano
影响因子：
6.6
作者：
Alfaidy, Nadia;Chauvet, Sylvain;Benharouga, Mohamed
通讯作者：
Benharouga, Mohamed
影响因子：
9.9
作者：
BENDHEIM, PE;BROWN, HR;BOLTON, DC
通讯作者：
BOLTON, DC
影响因子：
4
作者：
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通讯作者：
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