Signal integration and crosstalk during thymocyte migration and emigration.
Signal integration and crosstalk during thymocyte migration and emigration.
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DOI：
10.1038/nri2989
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发表时间：
2011-06-24
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The thymus produces self-tolerant functionally competent T cells. This occurs by the import of multipotent hematopoietic progenitors that are signalled to adopt the T cell fate. Expression of T cell specific genes, including those encoding the T cell receptor (TCR), is followed by positive and negative selection and the eventual export of mature T cells. Significant progress has been made in elucidating the signals that direct progenitor cell trafficking to, within and out of the thymus. These advances are the subject of this Review, with a particular focus on the role of reciprocal cooperative and regulatory interactions between TCR and chemokine receptor-mediated signalling.
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DOI：
10.1084/jem.20072168
发表时间：
2008-05-12
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Benz C;Martins VC;Radtke F;Bleul CC
通讯作者：
Bleul CC
影响因子：
5.4
作者：
Bupp, Melanie R. Gubbels;Edwards, Bonnie;Guo, Caiying;Wei, Datsen;Chen, Gang;Wong, Brian;Masteller, Emma;Peng, Stanford L.
通讯作者：
Peng, Stanford L.
影响因子：
32.4
作者：
Ciofani, Maria;Knowles, Gisele C.;Zuniga-Pflucker, Juan Carlos
通讯作者：
Zuniga-Pflucker, Juan Carlos
影响因子：
20.3
作者：
Davalos-Misslitz, Ana C. M.;Worbs, Tim;Foerster, Reinhold
通讯作者：
Foerster, Reinhold
影响因子：
32.4
作者：
Ehrlich, Lauren I. Richie;Oh, David Y.;Lewis, Richard S.
通讯作者：
Lewis, Richard S.