The stream of precursors that colonizes the thymus proceeds selectively through the early T lineage precursor stage of T cell development.
The stream of precursors that colonizes the thymus proceeds selectively through the early T lineage precursor stage of T cell development.
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DOI：
10.1084/jem.20072168
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发表时间：
2008-05-12
期刊：
影响因子：
--
通讯作者：
Bleul CC
中科院分区：
文献类型：
--
作者：
Benz C;Martins VC;Radtke F;Bleul CC
胸腺中的T细胞发育依赖于造血前体的持续定植。几种不同的T细胞前体细胞已被确定，但是否一个或几个独立的前体细胞类型维持胸腺生成尚不清楚。我们已经使用胸腺移植和诱导的谱系追踪系统，以确定胸腺内的前体细胞之间的先前描述的胸腺归巢祖细胞，引起胸腺中的T细胞谱系。在这些研究中未研究胸腺外前体。这两种方法都表明，T细胞谱系前体细胞的流，当进入胸腺，选择性地通过早期T谱系前体（ETP）阶段。迁移的前体细胞不表现出双阴性（DN）1c、DN 1d或DN 1 e阶段的特征，也不表现出含有共同淋巴前体2（CLP-2）或循环T细胞祖细胞（CTP）的胸腺等同物的群体的特征。仍然可能的是，未知的造血前体细胞或先前描述的具有CLP、CLP-2或CTP表型的胸腺外前体细胞通过绕过已知的胸腺内T细胞谱系祖细胞而进入T细胞发育。然而，很明显，在已知的胸腺内前体中，只有ETP群体对T细胞发育贡献了大量的T谱系前体。
T cell development in the thymus depends on continuous colonization by hematopoietic precursors. Several distinct T cell precursors have been identified, but whether one or several independent precursor cell types maintain thymopoiesis is unclear. We have used thymus transplantation and an inducible lineage-tracing system to identify the intrathymic precursor cells among previously described thymus-homing progenitors that give rise to the T cell lineage in the thymus. Extrathymic precursors were not investigated in these studies. Both approaches show that the stream of T cell lineage precursor cells, when entering the thymus, selectively passes through the early T lineage precursor (ETP) stage. Immigrating precursor cells do not exhibit characteristics of double-negative (DN) 1c, DN1d, or DN1e stages, or of populations containing the common lymphoid precursor 2 (CLP-2) or the thymic equivalent of circulating T cell progenitors (CTPs). It remains possible that an unknown hematopoietic precursor cell or previously described extrathymic precursors with a CLP, CLP-2, or CTP phenotype feed into T cell development by circumventing known intrathymic T cell lineage progenitor cells. However, it is clear that of the known intrathymic precursors, only the ETP population contributes significant numbers of T lineage precursors to T cell development.
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DOI：
10.1084/jem.20061442
发表时间：
2007-02-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Besseyrias V;Fiorini E;Strobl LJ;Zimber-Strobl U;Dumortier A;Koch U;Arcangeli ML;Ezine S;Macdonald HR;Radtke F
通讯作者：
Radtke F
影响因子：
14.9
作者：
Indra, AK;Warot, X;Metzger, D
通讯作者：
Metzger, D
影响因子：
64.8
作者：
WU, L;SCOLLAY, R;SHORTMAN, K
通讯作者：
SHORTMAN, K
影响因子：
30.5
作者：
Lambolez, F;Arcangeli, ML;Ezine, S
通讯作者：
Ezine, S
影响因子：
20.3
作者：
Maillard, I;Schwarz, BA;Pear, WS
通讯作者：
Pear, WS