Learned helplessness and social avoidance in the Wistar-Kyoto rat.
Learned helplessness and social avoidance in the Wistar-Kyoto rat.
复制标题
DOI：
10.3389/fnbeh.2014.00109
复制
发表时间：
2014
影响因子：
3
通讯作者：
Kerman IA
中科院分区：
文献类型：
--
作者：
Nam H;Clinton SM;Jackson NL;Kerman IA
Wistar-Kyoto (WKY) 大鼠是一种已建立的抑郁症模型，其特征是在各种测试中表现出焦虑和抑郁样行为。在这里，我们进一步表征了 WKY 大鼠中与抑郁症相关的特定行为和功能域的改变。此外，由于早期生活经历有力地塑造了情绪行为，我们还确定了 WKY 表型的各个方面是否可以通过使用新生儿处理或母亲分离的早期生活因素来改变。我们首先将 WKY 的行为与 Sprague–Dawley (SD)、Wistar 和自发性高血压 (SHR) 大鼠的行为进行比较：旷场测试、高架十字迷宫、新奇抑制喂养测试、社交互动测试和强迫游泳测试 (FST)。 WKY 在 FST 中表现出较高的基线不动性，并且是唯一在 FST 第 2 天与第 1 天相比表现出不动性增加的品系（习得性无助的指标）。与其他品系相比，WKY 还表现出更大的社交回避，以及更大的肾上腺和心脏。接下来我们测试了新生儿处理或早期母亲分离压力是否影响 WKY 的行为。这两种操作都没有影响他们的焦虑和抑郁样行为，这可能是由于他们的表型有强大的遗传基础。我们的研究结果表明，WKY 大鼠是一种有用的模型，可以捕获与临床抑郁症相关的特定功能域，包括：精神运动迟缓、行为抑制、习得性无助、社交退缩和生理功能障碍。 WKY 大鼠似乎对其他品系具有治疗作用的早期治疗（即新生儿处理）具有抵抗力，并且可能是开发针对治疗抵抗性抑郁症的个性化抗抑郁疗法的有用模型。
The Wistar-Kyoto (WKY) rat is an established depression model characterized by elevated anxiety- and depression-like behavior across a variety of tests. Here we further characterized specific behavioral and functional domains relevant to depression that are altered in WKY rats. Moreover, since early-life experience potently shapes emotional behavior, we also determined whether aspects of WKYs' phenotype were modifiable by early-life factors using neonatal handling or maternal separation. We first compared WKYs' behavior to that of Sprague–Dawley (SD), Wistar, and Spontaneously Hypertensive (SHR) rats in: the open field test, elevated plus maze, novelty-suppressed feeding test, a social interaction test, and the forced swim test (FST). WKYs exhibited high baseline immobility in the FST and were the only strain to show increased immobility on FST Day 2 vs. Day 1 (an indicator of learned helplessness). WKYs also showed greater social avoidance, along with enlarged adrenal glands and hearts relative to other strains. We next tested whether neonatal handling or early-life maternal separation stress influenced WKYs' behavior. Neither manipulation affected their anxiety- and depressive-like behaviors, likely due to a strong genetic underpinning of their phenotype. Our findings indicate that WKY rats are a useful model that captures specific functional domains relevant to clinical depression including: psychomotor retardation, behavioral inhibition, learned helplessness, social withdrawal, and physiological dysfunction. WKY rats appear to be resistant to early-life manipulations (i.e., neonatal handling) that are therapeutic in other strains, and may be a useful model for the development of personalized anti-depressant therapies for treatment resistant depression.
登录
查看更多内容
影响因子：
4.1
作者：
Gomez, F;Lahmame, A;Armario, A
通讯作者：
Armario, A
DOI：
10.1073/pnas.95.9.5335
发表时间：
1998-04-28
影响因子：
11.1
作者：
Caldji, C;Tannenbaum, B;Meaney, MJ
通讯作者：
Meaney, MJ
影响因子：
2.9
作者：
CIERPIAL, MA;SHASBY, DE;MCCARTY, R
通讯作者：
MCCARTY, R
影响因子：
3.6
作者：
Getachew, Bruk;Hauser, Sheketha R.;Tizabi, Yousef
通讯作者：
Tizabi, Yousef
影响因子：
2.9
作者：
Gunter, WD;Shepard, JD;Greenwood-Van Meerveld, B
通讯作者：
Greenwood-Van Meerveld, B