Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life.
Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life.
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DOI：
10.1016/j.clim.2009.07.003
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发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Bont L
中科院分区：
文献类型：
--
作者：
Belderbos ME;van Bleek GM;Levy O;Blanken MO;Houben ML;Schuijff L;Kimpen JL;Bont L
新生儿极易感染传染病，这可能是由于免疫反应受损所致。本研究旨在描述新生儿出生后第一个月内基于TLR的先天免疫的个体发育特征。比较了从无并发症妊娠和分娩后出生的健康新生儿（n=18）、1个月龄时获得的新生儿静脉血（n=96）和成人静脉血（n=17）中获得的脐带血的细胞构成和Toll样受体（TLR）激动剂诱导的细胞因子产生。脐带血TLR激动剂诱导的Th 1极化细胞因子IL-12 p70和IFN-α的产生通常受损，但对于TLR 3、7和9激动剂，在出生后的第一个月内迅速增加至成人水平。相比之下，TLR 4表现出较慢的成熟，LPS诱导的IL-12 p70产生较低，IL-10产生较高，直到一个月大。新生儿细胞因子对LPS反应的极化可能导致新生儿对严重细菌感染的易感性。
Newborns are highly susceptible to infectious diseases, which may be due to impaired immune responses. This study aims to characterize the ontogeny of neonatal TLR-based innate immunity during the first month of life. Cellularity and Toll-like receptor (TLR) agonist-induced cytokine production were compared between cord blood obtained from healthy neonates born after uncomplicated gestation and delivery (n=18), neonatal venous blood obtained at the age of one month (n=96), and adult venous blood (n=17). Cord blood TLR agonist-induced production of the Th1-polarizing cytokines IL-12p70 and IFN-α was generally impaired, but for TLR3, 7 and 9 agonists, rapidly increased to adult levels during the first month of life. In contrast, TLR4 demonstrated a slower maturation, with low LPS-induced IL-12p70 production and high IL-10 production up until the age of one month. Polarization in neonatal cytokine responses to LPS could contribute to neonatal susceptibility to severe bacterial infection.
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