Clinical update on cancer: molecular oncology of head and neck cancer.
Clinical update on cancer: molecular oncology of head and neck cancer.
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DOI：
10.1038/cddis.2013.548
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发表时间：
2014-01-23
影响因子：
9
通讯作者：
中科院分区：
文献类型：
--
作者：
头颈部癌包括一组不同种类的肿瘤，这些肿瘤通常在生物学上具有侵袭性。这些癌症仍然很难治疗，治疗可能会引起严重的长期副作用。对于不能通过手术和(或)化疗治愈的患者，几乎没有有效的治疗选择。迫切需要靶向治疗和预测生物标记物，以改善管理并将治疗毒性降至最低，并允许选择可能从非选择性和靶向治疗中受益的患者。这一临床更新旨在提供对该病分子发病机制的当前理解，并探索正在开发和临床试验的新疗法。
Head and neck cancers encompass a heterogeneous group of tumours that, in general, are biologically aggressive in nature. These cancers remain difficult to treat and treatment can cause severe, long-term side effects. For patients who are not cured by surgery and/or (chemo)radiotherapy, there are few effective treatment options. Targeted therapies and predictive biomarkers are urgently needed in order to improve the management and minimise the treatment toxicity, and to allow selection of patients who are likely to benefit from both nonselective and targeted therapies. This clinical update aims to provide an insight into the current understanding of the molecular pathogenesis of the disease, and explores the novel therapies under development and in clinical trials.
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DOI：
10.1158/1078-0432.ccr-08-3131
发表时间：
2009-04-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Avissar M;Christensen BC;Kelsey KT;Marsit CJ
通讯作者：
Marsit CJ
影响因子：
11.5
作者：
Brockstein, Bruce E.
通讯作者：
Brockstein, Bruce E.
影响因子：
158.5
作者：
Bonner, JA;Harari, PM;Ang, KK
通讯作者：
Ang, KK
影响因子：
3.5
作者：
Brunner, Thomas B.;Kunz-Schughart, Leoni A.;Baumann, Michael
通讯作者：
Baumann, Michael
DOI：
10.1056/nejmoa0912217
发表时间：
2010-07-01
期刊：
The New England journal of medicine
影响因子：
--
作者：
Ang KK;Harris J;Wheeler R;Weber R;Rosenthal DI;Nguyen-Tân PF;Westra WH;Chung CH;Jordan RC;Lu C;Kim H;Axelrod R;Silverman CC;Redmond KP;Gillison ML
通讯作者：
Gillison ML