Hair analysis provides a historical record of cortisol levels in Cushing's syndrome.
Hair analysis provides a historical record of cortisol levels in Cushing's syndrome.
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DOI：
10.1055/s-0029-1220771
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Van Uum SH
中科院分区：
文献类型：
--
作者：
Thomson S;Koren G;Fraser LA;Rieder M;Friedman TC;Van Uum SH
库欣综合征（CS）的严重程度取决于暴露于过量糖皮质激素的持续时间和程度。目前对血清、唾液和尿液中皮质醇的测量反映了样本采集时的全身皮质醇水平，但不能评估过去的皮质醇水平。CS患者的头发皮质醇水平可能会增加，并且，由于头发生长约1厘米/月，头发皮质醇的测量可以提供关于皮质醇增多症发展的历史信息。我们试图测量皮质醇在头发中的临床过程中，在6名女性CS患者和32名健康志愿者在1厘米的头发切片。使用市售的唾液皮质醇免疫测定法测量毛发皮质醇含量，该测定法具有修改后的用于毛发的方案。CS患者头发皮质醇水平高于对照组，中位数（范围）分别为679（279-2500）和116（26-204）ng/g（P <0.001）。分段毛发分析提供了采样前长达18个月的信息。头发皮质醇浓度出现不同，根据临床过程。基于这些数据，我们认为，头发皮质醇测量是一种新的方法，用于评估动态全身皮质醇暴露，并提供了独特的历史信息，皮质醇的变化，需要更多的研究，以充分了解这种技术的实用性和局限性。
The severity of Cushing’s Syndrome (CS) depends on the duration and extent of the exposure to excess glucocorticoids. Current measurements of cortisol in serum, saliva and urine reflect systemic cortisol levels at the time of sample collection, but cannot assess past cortisol levels. Hair cortisol levels may be increased in patients with CS, and, as hair grows about 1 cm/month, measurement of hair cortisol may provide historical information on the development of hypercortisolism. We attempted to measure cortisol in hair in relation to clinical course in six female patients with CS and in 32 healthy volunteers in 1 cm hair sections. Hair cortisol content was measured using a commercially available salivary cortisol immune assay with a protocol modified for use with hair. Hair cortisol levels were higher in patients with CS than in controls, the medians (ranges) were 679 (279–2500) and 116 (26–204) ng/g respectively (P <0.001). Segmental hair analysis provided information for up to 18 months before time of sampling. Hair cortisol concentrations appeared to vary in accordance with the clinical course. Based on these data, we suggest that hair cortisol measurement is a novel method for assessing dynamic systemic cortisol exposure and provides unique historical information on variation in cortisol, and that more research is required to fully understand the utility and limits of this technique.
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影响因子：
5.8
作者：
Arnaldi, G;Angeli, A;Boscaro, M
通讯作者：
Boscaro, M
影响因子：
4
作者：
Alonso, L;Fuchs, E
通讯作者：
Fuchs, E
影响因子：
2.2
作者：
Friedman, T. C.;Zuckerbraun, E.;Shahinian, H.
通讯作者：
Shahinian, H.
DOI：
10.1111/j.1749-6632.1951.tb31957.x
发表时间：
1951-01-01
影响因子：
5.2
作者：
MYERS, RJ;HAMILTON, JB
通讯作者：
HAMILTON, JB
DOI：
10.1080/10253890801887388
发表时间：
2008-01-01
影响因子：
2.3
作者：
Van Uum, S. H. M.;Sauve, B.;Koren, G.
通讯作者：
Koren, G.