Dual-phase imaging of cardiac metabolism using hyperpolarized pyruvate.
Dual-phase imaging of cardiac metabolism using hyperpolarized pyruvate.
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DOI：
10.1002/mrm.29042
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发表时间：
2022-01
影响因子：
3.3
通讯作者：
Park JM
中科院分区：
文献类型：
--
作者：
Ma J;Malloy CR;Pena S;Harrison CE;Ratnakar J;Zaha VG;Park JM
先前使用超极化(HP)[1-13C]丙酮酸的心脏成像研究是在舒张末(ED)获得的。心动周期与心肌中代谢物含量之间的相互作用知之甚少。在这项研究中，我们比较了HP丙酮酸及其产物在收缩末期(ES)和ED的图像。采用双时相~(13)C磁共振成像序列，以交错的方式在一个心动周期内以交错方式获取ES和ED的连续R-R间期的两幅HP图像。每名健康志愿者(n=3)接受两次HP[1-13C]丙酮酸盐注射，在短轴(SA)和垂直长轴(LA)平面上进行双时相成像。Hp 13C代谢物在心脏各时相的空间分布与多时相1H MRI相关，以证实机械变化。比较ES组和ED组心肌Hp代谢物的比例。在中腔SA平面上进行节段性分析。除机械改变外，用HP[1-13C]丙酮酸检测到的心脏代谢谱在ES和ED之间也不同。[13C]碳酸氢盐与[1-13C]乳酸的心肌信号在ED时明显小于ES时(p<；0.05)，尤其是在中前段和中下间隔段。心肌中不同的代谢特征可能反映了成像方法的技术方面，如冠状动脉血流，以及代谢的周期性变化。这项研究表明，由HP[1-13C]丙酮酸测量的心脏新陈代谢状况受到获得数据的心脏周期的影响。
Previous cardiac imaging studies using hyperpolarized (HP) [1-13C]pyruvate were acquired at end-diastole (ED). Little is known about the interaction between cardiac cycle and metabolite content in the myocardium. In this study, we compared images of HP pyruvate and products at end-systole (ES) and ED. A dual-phase 13C MRI sequence was implemented to acquire two sequential HP images within a single cardiac cycle at ES and ED during successive R-R intervals in an interleaved manner. Each healthy volunteer (n = 3) received two injections of HP [1-13C]pyruvate for the dual-phase imaging on the short-axis (SA) and the vertical long-axis (LA) planes. Spatial distribution of HP 13C metabolites at each cardiac phase was correlated to multi-phase 1H MRI to confirm the mechanical changes. Ratios of myocardial HP metabolites were compared between ES and ED. Segmental analysis was performed on the mid-cavity SA plane. Besides mechanical changes, metabolic profiles of the heart detected by HP [1-13C]pyruvate differed between ES and ED. The myocardial signal of [13C]bicarbonate relative to [1-13C]lactate was significantly smaller at ED than the ratio at ES (p < 0.05), particularly in mid-anterior and mid-inferoseptal segments. The distinct metabolic profiles in the myocardium likely reflect the technical aspects of the imaging approach such as the coronary flow in addition to the cyclical changes in metabolism. The study demonstrates that metabolic profiles of the heart, measured by HP [1-13C]pyruvate, are affected by the cardiac cycle that the data is acquired in.
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影响因子：
37.8
作者：
Cerqueira, MD;Weissman, NJ;Verani, MS
通讯作者：
Verani, MS
影响因子：
4.5
作者：
MORGENSTERN, C;HOLJES, U;LOCHNER, W
通讯作者：
LOCHNER, W
影响因子：
1.8
作者：
Antoni, Gunnar
通讯作者：
Antoni, Gunnar
影响因子：
3.3
作者：
Illing, B;Horn, M;Neubauer, S
通讯作者：
Neubauer, S
影响因子：
20.1
作者：
SPAAN, JAE;BREULS, NPW;LAIRD, JD
通讯作者：
LAIRD, JD