Regulation of Tissue Inflammation by 12-Lipoxygenases.
Regulation of Tissue Inflammation by 12-Lipoxygenases.
复制标题
通过12-脂氧酶调节组织炎症。
DOI：
10.3390/biom11050717
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发表时间：
2021-05-11
期刊：
影响因子：
5.5
通讯作者：
Casimiro I
中科院分区：
文献类型：
--
作者：
Kulkarni A;Nadler JL;Mirmira RG;Casimiro I
脂氧合酶(LOXs)是一种脂类代谢酶，催化多不饱和脂肪酸的双氧合反应生成活性二十烷类化合物。12-脂氧合酶(12-LOX)主要氧化底物的第12个碳。许多研究表明，12-LOX及其二十烷基类代谢物12-羟基二十碳四烯酸(12-HETE)在炎症性疾病中具有重要的病理意义。12-LOX活性水平的增加促进了应激(氧化和内质网)介导的炎症，导致这些组织的损伤。12-LOX还与免疫细胞的细胞迁移增强有关--这是几种代谢和自身免疫性疾病的特征。在各种疾病的动物模型中，该酶的基因枯竭或药物抑制已被证明在糖尿病、肺病、心血管疾病和代谢性疾病的动物模型中对疾病的发展和/或进展具有保护作用，这表明靶向该酶的翻译潜力可用于治疗几种疾病。在这篇文章中，我们回顾了12-LOX在一些疾病的发病机制中的作用，在这些疾病中，慢性炎症起着潜在的作用。
Lipoxygenases (LOXs) are lipid metabolizing enzymes that catalyze the di-oxygenation of polyunsaturated fatty acids to generate active eicosanoid products. 12-lipoxygenases (12-LOXs) primarily oxygenate the 12th carbon of its substrates. Many studies have demonstrated that 12-LOXs and their eicosanoid metabolite 12-hydroxyeicosatetraenoate (12-HETE), have significant pathological implications in inflammatory diseases. Increased level of 12-LOX activity promotes stress (both oxidative and endoplasmic reticulum)-mediated inflammation, leading to damage in these tissues. 12-LOXs are also associated with enhanced cellular migration of immune cells—a characteristic of several metabolic and autoimmune disorders. Genetic depletion or pharmacological inhibition of the enzyme in animal models of various diseases has shown to be protective against disease development and/or progression in animal models in the setting of diabetes, pulmonary, cardiovascular, and metabolic disease, suggesting a translational potential of targeting the enzyme for the treatment of several disorders. In this article, we review the role of 12-LOXs in the pathogenesis of several diseases in which chronic inflammation plays an underlying role.
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影响因子：
4.6
作者：
Cole BK;Morris MA;Grzesik WJ;Leone KA;Nadler JL
通讯作者：
Nadler JL
影响因子：
13.6
作者：
Dobrian, Anca D.;Lieb, David C.;Cole, Banumathi K.;Taylor-Fishwick, David A.;Chakrabarti, Swarup K.;Nadler, Jerry L.
通讯作者：
Nadler, Jerry L.
影响因子：
4.8
作者：
Conteh, Abass M.;Reissaus, Christopher A.;Linnemann, Amelia K.
通讯作者：
Linnemann, Amelia K.
脂氧合酶和环氧酶代谢：治疗和化学预防胰腺癌的新见解。
影响因子：
37.3
作者：
Ding, Xian-Zhong;Hennig, Rene;Adrian, Thomas E
通讯作者：
Adrian, Thomas E
DOI：
10.1161/atvbaha.109.185777
发表时间：
2009-06
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Chava KR;Karpurapu M;Wang D;Bhanoori M;Kundumani-Sridharan V;Zhang Q;Ichiki T;Glasgow WC;Rao GN
通讯作者：
Rao GN